7456-24-8
Chemical Structure
Dimethothiazine
Synonym(s): Dimetotiazine; Fonazine
- CAS No.: 7456-24-8
- Formula:C19H25N3O2S2
- Molecular Weight:391.55
IUPAC Name: 10-(2-(dimethylamino)propyl)-N,N-dimethyl-10H-phenothiazine-2-sulfonamide
InChIKey: VWNWVCJGUMZDIU-UHFFFAOYSA-N
SMILES: O=S(C(C=C1N2CC(N(C)C)C)=CC=C1SC3=C2C=CC=C3)(N(C)C)=O
Biological Activity: Dimethothiazine (Dimetotiazine; Fonazine) is an orally active tricyclic anti-histamine, anti-5-HT agent with a high activity against decerebrate rigidity, a little sedative activity and little soporific action. Dimethothiazine can reduce or abolish the effects of both static and dynamic fusimotor activity on the muscle spindle in decerebrate cat. Dimethothiazine can be used to research hemicrania and spasticity[1][2][3].
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Dimethothiazine | Dimethothiazine (Dimetotiazine; Fonazine) is an orally active tricyclic anti-histamine, anti-5-HT agent with a high activity against decerebrate rigidity, a little sedative activity and little soporific action. Dimethothiazine can reduce or abolish the effects of both static and dynamic fusimotor activity on the muscle spindle in decerebrate cat. Dimethothiazine can be used to research hemicrania and spasticity. | |||||||||||||||||||||
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- [1]. Nattero G, et al. Use of dimethothiazine in the prevention of hemicrania. Minerva Med. 1977 Mar 17;68(13):839-45. [Content Brief]
- [2]. Maxwell DR, Rhodes KF. The effects of dimethothiazine on muscle spindle activity in the decerebrate cat. Br J Pharmacol. 1970 Jul;39(3):520-32. [Content Brief]
- [3]. Griffiths MI, et al. The use of dimethothiazine in the treatment of childhood cerebral palsy. Dev Med Child Neurol. 1973 Feb;15(1):25-32. [Content Brief]
Keywords
