74639-14-8
Chemical Structure
Liquiritin apioside
- CAS No.: 74639-14-8
- Formula:C26H30O13
- Molecular Weight:550.51
IUPAC Name: (S)-2-(4-(((2S,3R,4S,5S,6R)-3-(((2S,3R,4R)-3,4-dihydroxy-4-(hydroxymethyl)tetrahydrofuran-2-yl)oxy)-4,5-dihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)phenyl)-7-hydroxychroman-4-one
InChIKey: FTVKHUHJWDMWIR-DWMQJYMWSA-N
SMILES: O[C@H]([C@H]1O[C@]2([H])OC[C@](O)(CO)[C@H]2O)[C@H](O)[C@@H](CO)O[C@H]1OC(C=C3)=CC=C3[C@@H]4CC(C5=CC=C(O)C=C5O4)=O
Biological Activity: Liquiritin apioside is an orally active inhibitor of TRPV1 receptor. Liquiritin apioside selectively inhibits laryngeal chemoreflex (LCR) and has no significant effect on mechanoreflex (LMR). Liquiritin apioside inhibits LCR by inhibiting reactive oxygen species (ROS) and NADPH oxidase, weakening the interaction between ROS and TRPV1. Liquiritin apioside can be used in the research of respiratory-related diseases[1][2].
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Liquiritin apioside | 99.96% | Liquiritin apioside is an orally active inhibitor of TRPV1 receptor. Liquiritin apioside selectively inhibits laryngeal chemoreflex (LCR) and has no significant effect on mechanoreflex (LMR). Liquiritin apioside inhibits LCR by inhibiting reactive oxygen species (ROS) and NADPH oxidase, weakening the interaction between ROS and TRPV1. Liquiritin apioside can be used in the research of respiratory-related diseases. | ||||||||||||||||||||
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Liquiritin apioside (Standard) | ≥98% | Liquiritin apioside (Standard) is the analytical standard of Liquiritin apioside. This product is intended for research and analytical applications. Liquiritin apioside, a main flavonoid component of licorice, possesses antitussive effects. | ||||||||||||||||||||
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- [1]. Wei W, et al. Liquiritin apioside attenuates laryngeal chemoreflex but not mechanoreflex in rat pups. Am J Physiol Lung Cell Mol Physiol. 2020 Jan 1;318 (1) :L89-L97. [Content Brief]
- [2]. Xia X, et al. Liquiritin apioside alleviates colonic inflammation and accompanying depression-like symptoms in colitis by gut metabolites and the balance of Th17/Treg. Phytomedicine. 2023 Nov;120:155039. [Content Brief]
