74885-09-9
74885-09-9
Chemical Structure
5-Carboxamidotryptamine
Synonym(s): 5-CT
- CAS No.: 74885-09-9
- Formula:C11H13N3O
- Molecular Weight:203.24
IUPAC Name: 3-(2-aminoethyl)-1H-indole-5-carboxamide
InChIKey: WKZLNEWVIAGNAW-UHFFFAOYSA-N
SMILES: O=C(C1=CC2=C(NC=C2CCN)C=C1)N
Biological Activity: 5-Carboxamidotryptamine (5-CT) is a 5-HT1A, 5-HT1B, 5-HT1D, 5-HT5A, 5-HT7 receptor agonist[1][2][3][4]. 5-Carboxamidotryptamine has a Ki value of 4.6 nM for cloned human 5-HT5A receptor. 5-Carboxamidotryptamine causes a dose-dependent reduction in rectal temperature of mice[3][4].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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5-Carboxamidotryptamine | 98.74% | 5-Carboxamidotryptamine (5-CT) is a 5-HT1A, 5-HT1B, 5-HT1D, 5-HT5A, 5-HT7 receptor agonist. 5-Carboxamidotryptamine has a Ki value of 4.6 nM for cloned human 5-HT5A receptor. 5-Carboxamidotryptamine causes a dose-dependent reduction in rectal temperature of mice. | ||||||||||||||||||||
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References
- [1]. Saxena PR,et al. Characterization of 5-hydroxytryptamine receptors in the cranial vasculature. Cephalalgia. 1989;9 Suppl 9:15-22. [Content Brief]
- [2]. Saxena PR, et al. From serotonin receptor classification to the antimigraine drug sumatriptan. Cephalalgia. 1992 Aug;12(4):187-96. [Content Brief]
- [3]. Guscott MR, Egan E, Cook GP, Stanton JA, Beer MS, Rosahl TW, Hartmann S, Kulagowski J, et al. The hypothermic effect of 5-CT in mice is mediated through the 5-HT7 receptor. Neuropharmacology. 2003 Jun;44(8):1031-7. [Content Brief]
- [4]. Hurley PT, et al. Functional coupling of a recombinant human 5-HT5A receptor to G-proteins in HEK-293 cells. Br J Pharmacol. 1998 Jul;124(6):1238-44. [Content Brief]
