756875-51-1
756875-51-1
Chemical Structure
K6PC-5
- CAS No.: 756875-51-1
- Formula:C19H37NO4
- Molecular Weight:343.50
IUPAC Name: N-(1,3-dihydroxypropan-2-yl)-2-hexyl-3-oxodecanamide
InChIKey: CGYVFCHCRBGGJG-UHFFFAOYSA-N
SMILES: CCCCCCCC(C(C(NC(CO)CO)=O)CCCCCC)=O
Biological Activity: K6PC-5, a ceramide derivative, is a sphingosine kinase 1(SPHK1) activator and elicites a rapid transient increase in intracellular calcium levels. K6PC-5 has the potential for skin diseases involving abnormal keratinocyte, and neurodegeneration and virus infection research[1][2][3].
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K6PC-5 | 99.27% | K6PC-5, a ceramide derivative, is a sphingosine kinase 1(SPHK1) activator and elicites a rapid transient increase in intracellular calcium levels. K6PC-5 has the potential for skin diseases involving abnormal keratinocyte, and neurodegeneration and virus infection research. | ||||||||||||||||||||
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Structural Analogs
-
Similarity Score 0.75
HY-125407Palmitoyl serinol -
Similarity Score 0.71
HY-121907N-Palmitoyl L-alanine -
Similarity Score 0.71
HY-W396889(R)-N-(1-Hydroxypropan-2-yl)palmitamide -
Similarity Score 0.70
HY-W009379N-Lauroyl-L-alanine -
Similarity Score 0.70
HY-117195Lauroyl lysine -
Similarity Score 0.69
HY-W074889N-Myristoylglycine -
Similarity Score 0.69
HY-W074888N-Lauroyl-L-glutamic acid -
Similarity Score 0.69
HY-129683AM3102 -
Similarity Score 0.69
HY-115428(R)-(+)-Linoleyl-1'-Hydroxy-2'-Propylamide -
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References
- [1]. Kwon YB, et al. Novel synthetic ceramide derivatives increase intracellular calcium levels and promote epidermal keratinocyte differentiation. J Lipid Res. 2007 Sep;48(9):1936-43. [Content Brief]
- [2]. Jong-Kyung Youm, et al. K6PC-5, a sphingosine kinase activator, induces anti-aging effects in intrinsically aged skin through intracellular Ca2+ signaling. J Dermatol Sci. 2008 Aug;51(2):89-102. [Content Brief]
- [3]. Imre G, et al. The sphingosine kinase 1 activator, K6PC-5, attenuates Ebola virus infection. iScience. 2021 Mar 5;24(4):102266. [Content Brief]
