76081-98-6
76081-98-6
Chemical Structure
SCH28080
- CAS No.: 76081-98-6
- Formula:C17H15N3O
- Molecular Weight:277.32
IUPAC Name: 2-(8-(benzyloxy)-2-methylimidazo[1,2-a]pyridin-3-yl)acetonitrile
InChIKey: PYKJFEPAUKAXNN-UHFFFAOYSA-N
SMILES: N#CCC1=C(C)N=C2C(OCC3=CC=CC=C3)=CC=CN21
Biological Activity: SCH28080 is a reversible, K+-competitive inhibitor of the gastric H,K-ATPase, with a Ki of 0.12 μM. SCH28080 is an effective inhibitor of acid secretion in vivo and with anti-gastric ulcer activity[1][2][3].
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SCH28080 | 99.0% | SCH28080 is a reversible, K+-competitive inhibitor of the gastric H,K-ATPase, with a Ki of 0.12 μM. SCH28080 is an effective inhibitor of acid secretion in vivo and with anti-gastric ulcer activity. | ||||||||||||||||||||
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SCH28080 (Standard) | ≥98% | SCH28080 (Standard) is the analytical standard of SCH28080. This product is intended for research and analytical applications. SCH28080 is a reversible, K+-competitive inhibitor of the gastric H,K-ATPase, with a Ki of 0.12 μM. SCH28080 is an effective inhibitor of acid secretion in vivo and with anti-gastric ulcer activity. | ||||||||||||||||||||
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References
- [1]. Scott CK, et al. Studies on the mechanism of action of the gastric microsomal (H+ + K+)-ATPase inhibitors SCH 32651 and SCH 28080. Biochem Pharmacol. 1987 Jan 1;36(1):97-104. [Content Brief]
- [2]. Martin Jakab, et al. The H+/K+ ATPase Inhibitor SCH-28080 Inhibits Insulin Secretion and Induces Cell Death in INS-1E Rat Insulinoma Cells. Cell Physiol Biochem. 2017;43(3):1037-1051. [Content Brief]
- [3]. Y Hamagishi, et al. Inhibitory Effects of Copiamycin A, a Macrocyclic Lactone Antibiotic, on Gastric H+,K(+)-ATPase, Acid Secretion and Ulcer Formation. Jpn J Pharmacol. 1991 Feb;55(2):283-6. [Content Brief]
Keywords
