76265-42-4
Chemical Structure
Beauverolide Ka
- CAS No.: 76265-42-4
- Formula:C37H50N4O5
- Molecular Weight:630.82
IUPAC Name: (3R,6S,9S,13S)-9-((1H-indol-3-yl)methyl)-6-benzyl-3-((S)-sec-butyl)-13-((S)-octan-2-yl)-1-oxa-4,7,10-triazacyclotridecane-2,5,8,11-tetraone
InChIKey: WCSIGBXTLAHHJM-YSEQWEHISA-N
SMILES: O=C(N[C@@H](C(O[C@@H](CC(N[C@@H](CC1=CNC2=C1C=CC=C2)C(N3)=O)=O)[C@@H](C)CCCCCC)=O)[C@@H](C)CC)[C@@H]3CC4=CC=CC=C4
Biological Activity: Beauverolide Ka, a cyclotetradepsipeptide, is a metabolite of Beauveria bassiana fungus. Beauverolide Ka stimulates glucose uptake in cultured rat L6 myoblasts at 50 μM. Beauverolide Ka exhibits protecting effects on HEI-OC1 cells at 10 μM and shows dose-dependent activity in both L6 myoblasts and myotubes[1][2].
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Beauverolide Ka | Beauverolide Ka, a cyclotetradepsipeptide, is a metabolite of Beauveria bassiana fungus. Beauverolide Ka stimulates glucose uptake in cultured rat L6 myoblasts at 50 μM. Beauverolide Ka exhibits protecting effects on HEI-OC1 cells at 10 μM and shows dose-dependent activity in both L6 myoblasts and myotubes. | |||||||||||||||||||||
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References
- [1]. Yuan-Fei Zhou, et al. 3-Hydroxy-4-methyldecanoic Acid-Containing Cyclotetradepsipeptides from an Endolichenic Beauveria sp. J Nat Prod. 2021 Apr 23;84(4):1244-1253. [Content Brief]
- [2]. Feifei Luo, et al. Differential metabolic responses of Beauveria bassiana cultured in pupae extracts, root exudates and its interactions with insect and plant. J Invertebr Pathol. 2015 Sep;130:154-64. [Content Brief]
