76733-91-0
76733-91-0
Chemical Structure
Coumaperine
- CAS No.: 76733-91-0
- Formula:C16H19NO2
- Molecular Weight:257.33
InChIKey: QDAARMDLSCDBFU-YPCIICBESA-N
SMILES: OC(C=C1)=CC=C1/C=C/C=C/C(N2CCCCC2)=O
Biological Activity: Coumaperine is an amide alkaloid. Coumaperine can be extracted from white piper. Coumaperine inhibits NF-κB. Coumaperine derivatives exhibit anticancer activity against non-small cell lung cancer and Hodgkin's lymphoma. Coumaperine derivatives have antibacterial activity[1][2].
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Coumaperine | Coumaperine is an amide alkaloid. Coumaperine can be extracted from white piper. Coumaperine inhibits NF-κB. Coumaperine derivatives exhibit anticancer activity against non-small cell lung cancer and Hodgkin's lymphoma. Coumaperine derivatives have antibacterial activity. | |||||||||||||||||||||
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References
- [1]. Nandakumar N, et al. Synthesis of coumaperine derivatives: Their NF-κB inhibitory effect, inhibition of cell migration and their cytotoxic activity. Eur J Med Chem. 2017 Jan 5;125:1076-1087. [Content Brief]
- [2]. Kadosh Y, et al. Quorum Sensing and NF-κB Inhibition of Synthetic Coumaperine Derivatives from Piper nigrum. Molecules. 2021 Apr 15;26(8):2293. [Content Brief]
