77234-90-3
Chemical Structure
Denzimol hydrochloride
- CAS No.: 77234-90-3
- Formula:C19H21ClN2O
- Molecular Weight:328.84
IUPAC Name: 2-(1H-imidazol-1-yl)-1-(4-phenethylphenyl)ethan-1-ol hydrochloride
InChIKey: RBDNRYIXZOBPMV-UHFFFAOYSA-N
SMILES: OC(C1=CC=C(CCC2=CC=CC=C2)C=C1)CN3C=CN=C3.Cl
Biological Activity: Denzimol hydrochloride is an orally active anticonvulsant agent. Denzimol hydrochloride inhibits cytochrome P450, and interacts with benzodiazepine receptors. Denzimol hydrochloride selectively antagonizes tonic components of Metrazol-induced seizures in rats and mice. Denzimol hydrochloride can be used for the research of epilepsy and convulsions[1][2][3][4][5][6].
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Denzimol hydrochloride | Denzimol hydrochloride is an orally active anticonvulsant agent. Denzimol hydrochloride inhibits cytochrome P450, and interacts with benzodiazepine receptors. Denzimol hydrochloride selectively antagonizes tonic components of Metrazol-induced seizures in rats and mice. Denzimol hydrochloride can be used for the research of epilepsy and convulsions. | |||||||||||||||||||||
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- [1]. Salmona M, et al. Interaction of the anticonvulsants, denzimol and nafimidone, with liver cytochrome P450 in the rat. J Pharm Pharmacol. 1988;40(1):17-21. [Content Brief]
- [2]. Caccia S, et al. Effect of the anticonvulsant denzimol on the disposition of diazepam in the rat. J Pharm Pharmacol. 1986 Jun;38(6):469-72. [Content Brief]
- [3]. Patsalos PN, et al. The interaction of denzimol (a new anticonvulsant) with carbamazepine and phenytoin. J Neurol Neurosurg Psychiatry. 1985 Apr;48(4):374-7. [Content Brief]
- [4]. Ibba M, et al. Differential antagonism of denzimol to various components of metrazol-induced seizures in rats and mice. Pharmacol Res Commun. 1985 Dec;17(12):1169-80. [Content Brief]
- [5]. Bertin D, et al. Determination of denzimol, a new anticonvulsant agent, and its main metabolite in biological material by gas chromatography and high-performance liquid chromatography. J Chromatogr. 1986 May 28;378(1):147-54. [Content Brief]
- [6]. Benassi E, et al. Preliminary note on the effect of denzimol in partial epilepsy. Ital J Neurol Sci. 1988 Aug;9(4):331-5. [Content Brief]
Keywords
