778630-77-6
Chemical Structure
Onzigolide
Synonym(s): BIM-23A760; TBR-760
- CAS No.: 778630-77-6
- Formula:C86H116N16O12S4
- Molecular Weight:1694.20
InChIKey: WLBJBODHTIKYSL-JFPOTJHNSA-N
SMILES: CCCN1[C@@]2([H])[C@@](C[C@H](C1)CSCC(N[C@H](CCCCNC(CSC[C@@H]3C[C@]4([H])C5=CC=CC6=C5C(C[C@@]4([H])N(C3)CCC)=CN6)=O)C(N[C@@H]7C(N[C@H](C(N[C@@H](C(N[C@H](C(N[C@H](C(N[C@@H](CSSC7)C(N[C@H](C(N)=O)[C@H](O)C)=O)=O)CC)=O)CCCCN)=O)CC8=CNC9=CC=CC=C89)=O)CC%10=CC=C(C=C%10)O)=O)=O)=O)([H])C%11=CC=CC%12=C%11C(C2)=CN%12
Biological Activity: Onzigolide (BIM-23A760), a chimeric dopamine-somatostatin compound, shows potent agonist activity at both DA type 2 (D2R) and SST type 2 (SSTR2) receptors[1][2].
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Onzigolide | Onzigolide (BIM-23A760), a chimeric dopamine-somatostatin compound, shows potent agonist activity at both DA type 2 (D2R) and SST type 2 (SSTR2) receptors. | |||||||||||||||||||||
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- [1]. Halem HA, et al. TBR-760, a Dopamine-Somatostatin Compound, Arrests Growth of Aggressive Nonfunctioning Pituitary Adenomas in Mice. Endocrinology. 2020 Aug 1;161(8):bqaa101. [Content Brief]
- [2]. Cuny T, et al. Characterization of the ability of a, second-generation SST-DA chimeric molecule, TBR-065, to suppress GH secretion from human GH-secreting adenoma cells. Pituitary. 2021 Jun;24(3):351-358. [Content Brief]
Keywords
