78459-19-5
Chemical Structure
Adimolol free base
Synonym(s): MEN-935 free base
- CAS. Nr.: 78459-19-5
- Formula:C25H29N3O3
- Molecular Weight:419.52
IUPAC Name: 1-(3-((2-hydroxy-3-(naphthalen-1-yloxy)propyl)amino)-3-methylbutyl)-1,3-dihydro-2H-benzo[d]imidazol-2-one
InChIKey: YWRIUGFSIQMHJK-UHFFFAOYSA-N
SMILES: OC(COC1=CC=CC2=CC=CC=C12)CNC(C)(C)CCN3C4=C(C=CC=C4)NC3=O
Biological Activity: Adimolol (free base) (MEN 935 (free base)) is an antagonist of β- and α-adrenolytic receptor. Adimolol (free base) shows Kis of 5.2 x 10-7, 1.3 x 10-5 mol/L at α1 and α2 drenoceptors, respectively. Adimolol (free base) can be used for antihypertensive study[1].
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Adimolol free base | Adimolol (free base) (MEN 935 (free base)) is an antagonist of β- and α-adrenolytic receptor. Adimolol (free base) shows Kis of 5.2 x 10-7, 1.3 x 10-5 mol/L at α1 and α2 drenoceptors, respectively. Adimolol (free base) can be used for antihypertensive study. | |||||||||||||||||||||
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- [1]. Palluk R, et al. Interactions of MEN 935 (adimolol), a long acting beta- and alpha-adrenolytic antihypertensive agent, with postsynaptic alpha-adrenoceptors in different isolated blood vessels--influence of angiotensin II. Naunyn Schmiedebergs Arch Pharmacol. 1986 Jul;333(3):277-83. [Content Brief]
Keywords
