791593-56-1
791593-56-1
Chemical Structure
BAY 74-4113
- CAS No.: 791593-56-1
- Formula:C26H20F2N2O3S
- Molecular Weight:478.51
IUPAC Name: (1R,2R)-2-(3'-fluoro-4'-((6-fluorobenzo[d]thiazol-2-yl)amino)-[1,1'-biphenyl]-4-carbonyl)cyclopentanecarboxylic acid
InChIKey: IOQRTGZPCYYQLE-RTBURBONSA-N
SMILES: FC1=CC=C2C(SC(NC3=C(C=C(C4=CC=C(C=C4)C([C@H]5[C@@H](CCC5)C(O)=O)=O)C=C3)F)=N2)=C1
Biological Activity: BAY 74-4113 is a DGAT1 inhibitor (IC50: 72 nM). BAY 74-4113 can be used in obesity research[1][2].
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BAY 74-4113 | BAY 74-4113 is a DGAT1 inhibitor (IC50: 72 nM). BAY 74-4113 can be used in obesity research. | |||||||||||||||||||||
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References
- [1]. Roger Smith, et al. Preparation and use of aryl alkyl acid derivatives for the treatment of obesity. US7091228B2. Bayer Pharmaceuticals Corp. 2004-05-06.
- [2]. Kandre S, et al. Synthesis and evaluation of cyclohexane carboxylic acid head group containing isoxazole and thiazole analogs as DGAT1 inhibitors. Eur J Med Chem. 2014 May 22;79:203-15. [Content Brief]
