79467-23-5
79467-23-5
Chemical Structure
Mioflazine
- CAS No.: 79467-23-5
- Formula:C29H30Cl2F2N4O2
- Molecular Weight:575.48
IUPAC Name: 1-(4,4-bis(4-fluorophenyl)butyl)-4-(2-((2,6-dichlorophenyl)amino)-2-oxoethyl)piperazine-2-carboxamide
InChIKey: VWXFUOAKGNJSBI-UHFFFAOYSA-N
SMILES: O=C(NC1=C(Cl)C=CC=C1Cl)CN2CC(C(N)=O)N(CCCC(C3=CC=C(F)C=C3)C4=CC=C(F)C=C4)CC2
Biological Activity: Mioflazine is an orally active nucleoside transport inhibitor with sleep-improving activity. Mioflazine significantly improves cardiac survival after global cardiac ischemia. Mioflazine inhibits nucleoside uptake Mioflazine does not exhibit inotropic effects during induction and nursing[1][2][3].
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Mioflazine | Mioflazine is an orally active nucleoside transport inhibitor with sleep-improving activity. Mioflazine significantly improves cardiac survival after global cardiac ischemia. Mioflazine inhibits nucleoside uptake Mioflazine does not exhibit inotropic effects during induction and nursing. | |||||||||||||||||||||
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References
- [1]. Wauquier A, et al. Sleep improvement in dogs after oral administration of mioflazine, a nucleoside transport inhibitor. Psychopharmacology (Berl). 1987;91(4):434-9. [Content Brief]
- [2]. Pirovano IM, et al. Inhibition of nucleoside uptake in human erythrocytes by a new series of compounds related to lidoflazine and mioflazine. Eur J Pharmacol. 1990 Dec 15;189(6):419-22. [Content Brief]
- [3]. J G Hugtenburg, et al. The influence of nifedipine and mioflazine on mitochondrial calcium overload in normoxic and ischaemic guinea-pig hearts. Eur J Pharmacol. 1990 Mar 13;178(1):71-8. [Content Brief]
