79514-49-1
Chemical Structure
Ap44mSe
- CAS No.: 79514-49-1
- Formula:C10H14N4Se
- Molecular Weight:269.20
IUPAC Name: (E)-N,N-dimethyl-2-(1-(pyridin-2-yl)ethylidene)hydrazine-1-carboselenoamide
InChIKey: XFYODGQDFXNBMQ-XYOKQWHBSA-N
SMILES: C/C(C1=NC=CC=C1)=N\NC(N(C)C)=[Se]
Biological Activity: Ap44mSe is a selenosemicarbazone that effectively depletes cellular Fe, resulting in transferrin receptor-1 up-regulation, ferritin down-regulation, and increased expression of the potent metastasis suppressor, N-myc downstream regulated gene-1. Ap44mSe forms redox active Cu complexes that target the lysosome to induce lysosomal membrane permeabilization[1].
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Ap44mSe | Ap44mSe is a selenosemicarbazone that effectively depletes cellular Fe, resulting in transferrin receptor-1 up-regulation, ferritin down-regulation, and increased expression of the potent metastasis suppressor, N-myc downstream regulated gene-1. Ap44mSe forms redox active Cu complexes that target the lysosome to induce lysosomal membrane permeabilization. | |||||||||||||||||||||
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Keywords
