80115-95-3
80115-95-3
Chemical Structure
N-Acetyl-Leukotriene E4
Synonym(s): N-Acetyl-LTE4
- CAS No.: 80115-95-3
- Formula:C25H39NO6S
- Molecular Weight:481.65
IUPAC Name: (5S,6R,7E,9E,11Z,14Z)-6-(((R)-2-acetamido-2-carboxyethyl)thio)-5-hydroxyicosa-7,9,11,14-tetraenoic acid
InChIKey: BGGYAYMMFYBWEX-HXDOPMNESA-N
SMILES: CCCCC/C=C\C/C=C\C=C\C=C\[C@@H](SC[C@H](NC(C)=O)C(O)=O)[C@@H](O)CCCC(O)=O
Biological Activity: N-Acetyl-Leukotriene E4 (N-Acetyl-LTE4) is a metabolite of Leukotriene E4 (LTE4) (HY-113465), which is detected in bile and urine[1]. N-Acetyl-Leukotriene E4 produces a vasoconstriction in the mesenteric vessels which led to reduction of blood flow to the gut[2].
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N-Acetyl-Leukotriene E4 | N-Acetyl-Leukotriene E4 (N-Acetyl-LTE4) is a metabolite of Leukotriene E4 (LTE4) (HY-113465), which is detected in bile and urine. N-Acetyl-Leukotriene E4 produces a vasoconstriction in the mesenteric vessels which led to reduction of blood flow to the gut. | |||||||||||||||||||||
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References
- [1]. Uemura M, et al., Cysteinyl leukotrienes in the urine of patients with liver diseases. Hepatology. 1994 Oct;20(4 Pt 1):804-12. [Content Brief]
- [2]. Siren AL, et al., N-acetyl-leukotriene E4 is a potent constrictor of rat mesenteric vessels. Eur J Pharmacol. 1988 Feb 9;146(2-3):331-5. [Content Brief]
