803647-40-7
803647-40-7
Chemical Structure
NSC59984
- CAS No.: 803647-40-7
- Formula:C12H15N3O4
- Molecular Weight:265.27
IUPAC Name: (E)-1-(4-methylpiperazin-1-yl)-3-(5-nitrofuran-2-yl)prop-2-en-1-one
InChIKey: QKTRIGNWBRHBFV-DUXPYHPUSA-N
SMILES: O=C(N1CCN(C)CC1)/C=C/C2=CC=C([N+]([O-])=O)O2
Biological Activity: NSC59984 induces mutant p53 protein degradation via MDM2 and the ubiquitin-proteasome pathway[1]. NSC59984 acts by targeting GOF-mutant p53 and stimulates p73 to restore the p53 pathway signaling[2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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NSC59984 | 99.43% | NSC59984 induces mutant p53 protein degradation via MDM2 and the ubiquitin-proteasome pathway. NSC59984 acts by targeting GOF-mutant p53 and stimulates p73 to restore the p53 pathway signaling. | ||||||||||||||||||||
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References
- [1]. Zhang S, et al. Small-Molecule NSC59984 Restores p53 Pathway Signaling and Antitumor Effects against Colorectal Cancer via p73 Activation and Degradation of Mutant p53. Cancer Res. 2015 Sep 15;75(18):3842-52. [Content Brief]
- [2]. Zhang S, et al. Small-Molecule NSC59984 Restores p53 Pathway Signaling and Antitumor Effects againstColorectal Cancer via p73 Activation and Degradation of Mutant p53. Cancer Res. 2015 Sep 15;75(18):3842-52. [Content Brief]
Keywords
