808756-64-1
808756-64-1
Chemical Structure
A778317
- CAS No.: 808756-64-1
- Formula:C23H25N3O
- Molecular Weight:359.46
IUPAC Name: (R)-1-(5-(tert-butyl)-2,3-dihydro-1H-inden-1-yl)-3-(isoquinolin-5-yl)urea
InChIKey: VPSCJCQPUGKRNC-OAQYLSRUSA-N
SMILES: O=C(N[C@@H]1CCC2=C1C=CC(C(C)(C)C)=C2)NC3=CC=CC4=C3C=CN=C4
Biological Activity:
A778317 is a TRPV1 antagonists. A778317 can block changes in intracellular calcium levels mediated by TRPV1 receptors, with a pIC50 value of 8.31. A-778317 can also block the activation of natural rat TRPV1 receptors in dorsal root ganglion neurons by capsaicin and acid[1].
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A778317 | A778317 is a TRPV1 antagonists. A778317 can block changes in intracellular calcium levels mediated by TRPV1 receptors, with a pIC50 value of 8.31. A-778317 can also block the activation of natural rat TRPV1 receptors in dorsal root ganglion neurons by capsaicin and acid. |
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Keywords
