81167-16-0
81167-16-0
Chemical Structure
Imiloxan
Synonym(s): RS 21361 free base
- CAS No.: 81167-16-0
- Formula:C14H16N2O2
- Molecular Weight:244.29
IUPAC Name: 2-((2,3-dihydrobenzo[b][1,4]dioxin-2-yl)methyl)-1-ethyl-1H-imidazole
InChIKey: UXABARREKCJULM-UHFFFAOYSA-N
SMILES: CCN1C=CN=C1CC2OC3=CC=CC=C3OC2
Biological Activity: Imiloxan (RS 21361) is a potent and selective alpha 2B-adrenoceptor antagonist. Imiloxan produces a dose-related reversal of Guanoxabenz (HY-U00123)-induced maximal mydriasis in male rats. Imiloxan has the potential for acute kidney injury research[1][2][3].
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Imiloxan | Imiloxan (RS 21361) is a potent and selective alpha 2B-adrenoceptor antagonist. Imiloxan produces a dose-related reversal of Guanoxabenz (HY-U00123)-induced maximal mydriasis in male rats. Imiloxan has the potential for acute kidney injury research. | |||||||||||||||||||||
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References
- [1]. Berridge TL, et al. alpha 2-Adrenoceptor agonists induced mydriasis in the rat by an action within the central nervous system. Br J Pharmacol. 1983 Mar;78(3):507-15. [Content Brief]
- [2]. A D Michel, et al. Assessment of imiloxan as a selective alpha 2B-adrenoceptor antagonist. Br J Pharmacol. 1990 Mar;99(3):560-4. [Content Brief]
- [3]. Takaomi Shimokawa, et al. Renoprotective effect of yohimbine on ischaemia/reperfusion-induced acute kidney injury through α2C-adrenoceptors in rats. Eur J Pharmacol. 2016 Jun 15;781:36-44. [Content Brief]
