82414-35-5
Chemical Structure
N1,N8-Diacetylspermidine
- CAS. Nr.: 82414-35-5
- Formula:C11H23N3O2
- Molecular Weight:229.32
IUPAC Name: N-(3-((4-acetamidobutyl)amino)propyl)acetamide
InChIKey: BKCVMAZDKFQPHB-UHFFFAOYSA-N
SMILES: CC(NCCCNCCCCNC(C)=O)=O
Biological Activity: N1,N8-Diacetylspermidine is a diacetylated polyamine metabolite and also a urine biomarker associated with diagnosis, prognosis and disease severity. Urinary levels of N1,N8-Diacetylspermidine increase in breast cancer, colorectal cancer, urogenital malignancies and Parkinson's disease. N1,N8-Diacetylspermidine can be used in studies related to breast cancer, colorectal cancer, urogenital malignancies and Parkinson's disease[1][2][3].
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N1,N8-Diacetylspermidine | 99.96% | N1,N8-Diacetylspermidine is a diacetylated polyamine metabolite and also a urine biomarker associated with diagnosis, prognosis and disease severity. Urinary levels of N1,N8-Diacetylspermidine increase in breast cancer, colorectal cancer, urogenital malignancies and Parkinson's disease. N1,N8-Diacetylspermidine can be used in studies related to breast cancer, colorectal cancer, urogenital malignancies and Parkinson's disease. | ||||||||||||||||||||
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N1,N8-Diacetylspermidine-d6 | N1,N8-Diacetylspermidine-d6 is the deuterium labeled N1,N8-Diacetylspermidine (HY-129912). N1,N8-Diacetylspermidine is a polyamines in the human urine. N1,N8-Diacetylspermidine is useful as prognostic indicators after treatment and during follow-up examination of cancer patients. | |||||||||||||||||||||
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References
- [1]. Umemori Y, et al. Evaluating the utility of N1,N12-diacetylspermine and N1,N8-diacetylspermidine in urine as tumor markers for breast and colorectal cancers. Clinica chimica acta; international journal of clinical chemistry. 2010 Dec 14;411(23-24):1894-9. [Content Brief]
- [2]. Hiramatsu K, et al. Diagnostic and prognostic usefulness of N1,N8-diacetylspermidine and N1,N12-diacetylspermine in urine as novel markers of malignancy. Journal of cancer research and clinical oncology. 1997;123(10):539-45. [Content Brief]
- [3]. Saiki S, et al. A metabolic profile of polyamines in parkinson disease: A promising biomarker. Ann Neurol. 2019 Aug;86(2):251-263. [Content Brief]
