826998-10-1
826998-10-1
Chemical Structure
D44
- CAS No.: 826998-10-1
- Formula:C16H16N4OS
- Molecular Weight:312.39
IUPAC Name: 2-((3H-imidazo[4,5-b]pyridin-2-yl)thio)-N-(2-ethylphenyl)acetamide
InChIKey: LGTSSAOGGPBTGN-UHFFFAOYSA-N
SMILES: O=C(CSC1=NC2=CC=CN=C2N1)NC3=CC=CC=C3CC
Biological Activity: D44 is a Plasmodium FKBP35 inhibitor that selectively inhibits the FKBD35 PPIase activity, with PPIase IC50 values of 132 nM and 125 nM for Plasmodium falciparum and Plasmodium vivax, respectively. D44 exhibits antiplasmodium activity and can be used in research related to infectious diseases[1][2].
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D44 | D44 is a Plasmodium FKBP35 inhibitor that selectively inhibits the FKBD35 PPIase activity, with PPIase IC50 values of 132 nM and 125 nM for Plasmodium falciparum and Plasmodium vivax, respectively. D44 exhibits antiplasmodium activity and can be used in research related to infectious diseases. | |||||||||||||||||||||
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References
- [1]. Atack TC, et al. Targeted Covalent Inhibition of Plasmodium FK506 Binding Protein 35. ACS Med Chem Lett. 2020 Sep 1;11(11):2131-2138. [Content Brief]
- [2]. Harikishore A, et al. Small molecule Plasmodium FKBP35 inhibitor as a potential antimalaria agent[J]. Scientific reports, 2013, 3(1): 2501. [Content Brief]
Keywords
