82845-85-0
82845-85-0
Chemical Structure
5-Methyluridine-d4
- CAS No.: 82845-85-0
- Formula:C10H10D4N2O6
- Molecular Weight:262.25
IUPAC Name: 1-((2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-(methyl-d3)pyrimidine-2,4(1H,3H)-dione-6-d
InChIKey: DWRXFEITVBNRMK-VZFAMDNFSA-N
SMILES: O[C@H]1[C@@H](O)[C@H](N2C(NC(C(C([2H])([2H])[2H])=C2[2H])=O)=O)O[C@@H]1CO
Biological Activity: 5-Methyluridine-d4 is the deuterium labeled 5-Methyluridine[1]. 5-Methyluridine is a is an endogenous methylated nucleoside found in human fluids[2].
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5-Methyluridine-d4 | 99.96% | 5-Methyluridine-d4 is the deuterium labeled 5-Methyluridine. 5-Methyluridine is a is an endogenous methylated nucleoside found in human fluids. | ||||||||||||||||||||
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5-Methyluridine (Standard) | ≥98% | 5-Methyluridine (Standard) is the analytical standard of 5-Methyluridine. This product is intended for research and analytical applications. 5-Methyluridine is a is an endogenous methylated nucleoside found in human fluids. | ||||||||||||||||||||
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5-Methyluridine-5′-13C | 5-Methyluridine-5′-13C is the 13C labeled 5-Methyluridine. 5-Methyluridine is a is an endogenous methylated nucleoside found in human flu. | |||||||||||||||||||||
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5-Methyluridine-13C5 | 5-Methyluridine-13C5 is 13C labeled 5-Methyluridine. | |||||||||||||||||||||
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5-Methyluridine-1′-13C | 5-Methyluridine-1′-13C is the 13C labeled 5-Methyluridine. 5-Methyluridine is a is an endogenous methylated nucleoside found in human flu. | |||||||||||||||||||||
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5-Methyluridine-2′-13C | 5-Methyluridine-2′-13C is the 13C labeled 5-Methyluridine. 5-Methyluridine is a is an endogenous methylated nucleoside found in human flu. | |||||||||||||||||||||
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5-Methyluridine-3′-13C | 5-Methyluridine-3′-13C is the 13C labeled 5-Methyluridine. 5-Methyluridine is a is an endogenous methylated nucleoside found in human flu. | |||||||||||||||||||||
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5-Methyluridine | 99.89% | 5-Methyluridine (m5U) is an RNA modified nucleotide generated by RNA methyltransferases (such as TrmA and RumA), which mainly targets specific uracil sites in RNA molecules such as the T arm of tRNA and rRNA. 5-Methyluridine relies on enzyme recognition of RNA secondary/tertiary structures (such as the T loop of tRNA or the specific stem-loop structure of rRNA) and participates in physiological processes such as translation accuracy and ribosome function by stabilizing RNA folding or regulating base pairing. | ||||||||||||||||||||
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References
- [1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216. [Content Brief]
- [2]. Yang TH, et al. Intracellular levels of S-adenosylhomocysteine but not homocysteine are highly correlated to the expression of nm23-H1 and the level of 5-methyldeoxycytidine in human hepatoma cells with different invasion activities. Nutr Cancer. 2006;55(2):224-31. [Content Brief]
