83058-69-9
83058-69-9
Chemical Structure
TEI-6122
Synonym(s): TFC 612
- CAS No.: 83058-69-9
- Formula:C22H38O5S
- Molecular Weight:414.60
IUPAC Name: methyl 6-(((1R,2S,3R)-3-hydroxy-2-((3S,5R,E)-3-hydroxy-5-methylnon-1-en-1-yl)-5-oxocyclopentyl)thio)hexanoate
InChIKey: KMYUINCCFSNYPC-QHUARRPLSA-N
SMILES: COC(CCCCCS[C@@H]1[C@H]([C@H](O)CC1=O)/C=C/[C@@H](O)C[C@H](C)CCCC)=O
Biological Activity: TEI-6122 is a 7-thiaprostaglandin E1 derivative. TEI-6122 can reduce urinary protein and suppressthe increase of blood urea nitrogen. TEI-6122 can inhibit monocyte chemoattractant protein-1 induced chemotaxis. TEI-6122 can be used for the research of inflammation, such as nephritis[1][2].
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TEI-6122 | TEI-6122 is a 7-thiaprostaglandin E1 derivative. TEI-6122 can reduce urinary protein and suppressthe increase of blood urea nitrogen. TEI-6122 can inhibit monocyte chemoattractant protein-1 induced chemotaxis. TEI-6122 can be used for the research of inflammation, such as nephritis. | |||||||||||||||||||||
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References
- [1]. Nagamatsu T, et al. Antinephritic effects of PGE1 and thiaprostaglandin E1, TEI-5178 and TEI-6122, on crescentic-type anti-GBM nephritis in rats. Jpn J Pharmacol. 1989 Dec;51(4):521-30. [Content Brief]
- [2]. Tanaka H, et al. The effect of a synthetic 7-thiaprostaglandin E1 derivative, TEI-6122, on monocyte chemoattractant protein-1 induced chemotaxis in THP-1 cells. Br J Pharmacol. 1995 Oct;116(4):2298-302. [Content Brief]
