83058-94-0
Chemical Structure
Terrecyclic Acid
- CAS No.: 83058-94-0
- Formula:C15H20O3
- Molecular Weight:248.32
IUPAC Name: (3aS,4R,7R,7aR)-8,8-dimethyl-3-methylene-2-oxooctahydro-3a,7-ethanoindene-4-carboxylic acid
InChIKey: SMAWCSOVJJHIOI-JNIYBQFBSA-N
SMILES: OC([C@H](CC1)[C@@](C2)(C3=C)[C@@](CC3=O)([H])[C@]1([H])C2(C)C)=O
Biological Activity: Terrecyclic acid is a sesquiterpene originally isolated from A. terreus with antibiotic and anticancer activity. It is active against S. aureus, B. subtilis, and M. roseus (MICs=25, 50, and 25 μg/mL, respectively). Terrecyclic acid induces a heat shock response, increases levels of reactive oxygen species (ROS), and inhibits NF-κB activity and cell growth in 3T3-Y9-B12 cells.2 In vivo, terrecyclic acid (0.1, 1, and 10 mg/ml) reduces the number of ascitic fluid tumor cells in a mouse model of P388 murine leukemia.
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Terrecyclic Acid | Terrecyclic acid is a sesquiterpene originally isolated from A. terreus with antibiotic and anticancer activity. It is active against S. aureus, B. subtilis, and M. roseus (MICs=25, 50, and 25 μg/mL, respectively). Terrecyclic acid induces a heat shock response, increases levels of reactive oxygen species (ROS), and inhibits NF-κB activity and cell growth in 3T3-Y9-B12 cells.2 In vivo, terrecyclic acid (0.1, 1, and 10 mg/ml) reduces the number of ascitic fluid tumor cells in a mouse model of P388 murine leukemia. | |||||||||||||||||||||
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Keywords
