83435-58-9
83435-58-9
Chemical Structure
N-Boc-D-prolinol
- CAS No.: 83435-58-9
- Formula:C10H19NO3
- Molecular Weight:201.27
IUPAC Name: tert-butyl (R)-2-(hydroxymethyl)pyrrolidine-1-carboxylate
InChIKey: BFFLLBPMZCIGRM-MRVPVSSYSA-N
SMILES: O=C(N1[C@H](CCC1)CO)OC(C)(C)C
Biological Activity: N-Boc-D-prolinol is a protected chiral proline derivative. N-Boc-D-prolinol facilitates the synthesis of highly selective histamine H1 and H3 receptor antagonists. N-Boc-D-prolinol can be used in the research of allergic rhinitis[1][2].
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N-Boc-D-prolinol | N-Boc-D-prolinol is a protected chiral proline derivative. N-Boc-D-prolinol facilitates the synthesis of highly selective histamine H1 and H3 receptor antagonists. N-Boc-D-prolinol can be used in the research of allergic rhinitis. | |||||||||||||||||||||
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References
- [1]. Procopiou PA, et al. The discovery of phthalazinone-based human H1 and H3 single-ligand antagonists suitable for intranasal administration for the treatment of allergic rhinitis. J Med Chem. 2011 Apr 14;54(7):2183-95. [Content Brief]
- [2]. Procopiou PA, et al. Synthesis and pharmacological investigation of azaphthalazinone human histamine H(1) receptor antagonists. Bioorg Med Chem. 2012 Oct 15;20(20):6097-108. [Content Brief]
Keywords
