84012-69-1
Chemical Structure
GlcNAc-1-Phosphotransferase
- CAS No.: 84012-69-1
- Formula:N/A
- Molecular Weight:N/A
SMILES: [GlcNAc-1-Phosphotransferase]
Biological Activity: GlcNAc-1-Phosphotransferase is a Golgi membrane-bound glycosylphosphotransferase. GlcNAc-1-Phosphotransferase is composed of an α/β catalytic subunit encoded by the GNPTAB gene and a γ regulatory subunit encoded by the GNPTG gene, forming an α2β2γ2 hexameric complex. GlcNAc-1-Phosphotransferase catalyzes the transfer of GlcNAc-1-phosphate from UDP-GlcNAc to the C-6 hydroxyl group of terminal mannose residues on high-mannose-type N-glycans, thereby initiating the mannose-6-phosphate tagging pathway. GlcNAc-1-Phosphotransferase loss-of-function mutations can lead to lysosomal storage diseases such as mucolipidosis type II/III. GlcNAc-1-Phosphotransferase can be used in research related to mucolipidosis[1][2][3].
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GlcNAc-1-Phosphotransferase | GlcNAc-1-Phosphotransferase is a Golgi membrane-bound glycosylphosphotransferase. GlcNAc-1-Phosphotransferase is composed of an α/β catalytic subunit encoded by the GNPTAB gene and a γ regulatory subunit encoded by the GNPTG gene, forming an α2β2γ2 hexameric complex. GlcNAc-1-Phosphotransferase catalyzes the transfer of GlcNAc-1-phosphate from UDP-GlcNAc to the C-6 hydroxyl group of terminal mannose residues on high-mannose-type N-glycans, thereby initiating the mannose-6-phosphate tagging pathway. GlcNAc-1-Phosphotransferase loss-of-function mutations can lead to lysosomal storage diseases such as mucolipidosis type II/III. GlcNAc-1-Phosphotransferase can be used in research related to mucolipidosis. | |||||||||||||||||||||
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References
- [1]. Mitachi K, et al. Novel FR-900493 analogues that inhibit the outgrowth of Clostridium difficile spores. ACS omega. 2018 Feb 28;3(2):1726-39.
- [2]. Huang J, et al. Dual-functional titanium (IV) immobilized metal affinity chromatography approach for enabling large-scale profiling of protein mannose-6-phosphate glycosylation and revealing its predominant substrates. Analytical chemistry. 2019 Sep 17;91(18):11589-97.
- [3]. Du S, Wang G, Zhang Z, Ma C, Gao N, Xiao J. Structural insights into how GlcNAc-1-phosphotransferase directs lysosomal protein transport. J Biol Chem. 2022 Mar;298(3):101702. [Content Brief]
