841-67-8
841-67-8
Chemical Structure
(S)-Thalidomide
Synonym(s): (S)-(-)-Thalidomide
- CAS No.: 841-67-8
- Formula:C13H10N2O4
- Molecular Weight:258.23
IUPAC Name: (S)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione
InChIKey: UEJJHQNACJXSKW-VIFPVBQESA-N
SMILES: O=C1N([C@@H](CC2)C(NC2=O)=O)C(C3=C1C=CC=C3)=O
Biological Activity: (S)-Thalidomide ((S)-(-)-Thalidomide) is the S-enantiomer of Thalidomide. (S)-Thalidomide has immunomodulatory, anti-inflammatory, antiangiogenic and pro-apoptotic effects[1][2][3]. (S)-Thalidomide induces teratogenic effects by binding to cereblon (CRBN) [4].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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(S)-Thalidomide | 99.52% | (S)-Thalidomide ((S)-(-)-Thalidomide) is the S-enantiomer of Thalidomide. (S)-Thalidomide has immunomodulatory, anti-inflammatory, antiangiogenic and pro-apoptotic effects. (S)-Thalidomide induces teratogenic effects by binding to cereblon (CRBN) . | ||||||||||||||||||||
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References
- [1]. Liu WM, et al. s-thalidomide has a greater effect on apoptosis than angiogenesis in a multiple myeloma cell line. Hematol J. 2004;5(3):247-54. [Content Brief]
- [2]. Stephens TD. The effect of thalidomide in chicken embryos. Birth Defects Res A Clin Mol Teratol. 2009 Aug;85(8):725-31. [Content Brief]
- [3]. Murphy S, et al. Enantioselectivity of thalidomide serum and tissue concentrations in a rat glioma model and effects of combination treatment with cisplatin and BCNU. J Pharm Pharmacol. 2007 Jan;59(1):105-14. [Content Brief]
- [4]. Tokunaga E, et al. Understanding the Thalidomide Chirality in Biological Processes by the Self-disproportionation of Enantiomers. Sci Rep. 2018 Nov 20;8(1):17131. [Content Brief]
Keywords
