844435-10-5
Chemical Structure
AJI-100
- CAS No.: 844435-10-5
- Formula:C17H14FN5O
- Molecular Weight:323.32
InChIKey: IBAUSYCHSXHDOA-UHFFFAOYSA-N
SMILES: O=C(C1=CC=C(NC2=NC=C(C(NC3=CC=CC=C3)=N2)F)C=C1)N
Biological Activity: AJI-100 is a dual-target inhibitor of Aurora kinase A and JAK2 with IC50 values of 12.7 nM and 18.5 nM, respectively. AJI-100 directly blocks Aurora kinase A to inhibit T cell mitosis and cell polarity, and inhibits JAK2 activation to inhibit STAT3 phosphorylation, thereby reducing the differentiation of TH1 and TH17 cells. AJI-100 can be used in studies on regulating immune responses and preventing graft-versus-host disease (GVHD)[1].
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AJI-100 | AJI-100 is a dual-target inhibitor of Aurora kinase A and JAK2 with IC50 values of 12.7 nM and 18.5 nM, respectively. AJI-100 directly blocks Aurora kinase A to inhibit T cell mitosis and cell polarity, and inhibits JAK2 activation to inhibit STAT3 phosphorylation, thereby reducing the differentiation of TH1 and TH17 cells. AJI-100 can be used in studies on regulating immune responses and preventing graft-versus-host disease (GVHD). | |||||||||||||||||||||
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Keywords
