84746-00-9
84746-00-9
Chemical Structure
1-Oleoyl-2-acetylglycerol
- CAS. Nr.: 84746-00-9
- Formula:C23H42O5
- Molecular Weight:398.58
IUPAC Name: 2-acetoxy-3-hydroxypropyl oleate
InChIKey: PWTCCMJTPHCGMS-KHPPLWFESA-N
SMILES: C(COC(CCCCCCC/C=C\CCCCCCCC)=O)(OC(C)=O)CO
Biological Activity: 1-Oleoyl-2-acetylglycerol is a membrane-permeable diacylglycerol analog and PKC activator. 1-Oleoyl-2-acetylglycerol activates TRPC3 channels. 1-Oleoyl-2-acetylglycerol attenuates D609 (HY-70072)-induced Apoptosis. 1-Oleoyl-2-acetylglycerol effectively stimulates insulin secretion. 1-Oleoyl-2-acetylglycerol can be used in research on monocytic leukemia[1][2][3][4][5][6].
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1-Oleoyl-2-acetylglycerol | 1-Oleoyl-2-acetylglycerol is a membrane-permeable diacylglycerol analog and PKC activator. 1-Oleoyl-2-acetylglycerol activates TRPC3 channels. 1-Oleoyl-2-acetylglycerol attenuates D609 (HY-70072)-induced Apoptosis. 1-Oleoyl-2-acetylglycerol effectively stimulates insulin secretion. 1-Oleoyl-2-acetylglycerol can be used in research on monocytic leukemia. | |||||||||||||||||||||
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References
- [1]. Iizuka H, et al. Effects of the tumor promoter, phorbol 12-myristate, 13-acetate, on the epidermal adenylate cyclase system: evidence for adenylate cyclase-regulation by protein kinase C. The Journal of investigative dermatology. 1989 Sep;93(3):387-91.
- [2]. Jordan ML, et al. Evidence that protein kinase C regulates allosensitized T lymphocyte function. The Journal of surgical research. 1991 Jun;50(6):569-73.
- [3]. Chen Y, et al. Structural mechanism of the agonist binding on human TRPC3 channel. Nature communications. 2025 Oct 22;16(1):9343. [Content Brief]
- [4]. Meng A, et al. Sphingomyelin synthase as a potential target for D609-induced apoptosis in U937 human monocytic leukemia cells. Experimental cell research. 2004 Jan 15;292(2):385-92.
- [5]. Werz O, et al. Development of 5-lipoxygenase inhibitors--lessons from cellular enzyme regulation. Biochemical pharmacology. 2005 Aug 01;70(3):327-33.
- [6]. Li GD, et al. Potentiation of stimulus-induced insulin secretion in protein kinase C-deficient RINm5F cells. The Biochemical journal. 1990 Dec 15;272(3):637-45.
