847727-81-5
Chemical Structure
AAT-008
- CAS No.: 847727-81-5
- Formula:C21H16ClFN2O4
- Molecular Weight:414.81
IUPAC Name: (S)-4-(1-(5-chloro-2-(3-fluorophenoxy)nicotinamido)ethyl)benzoic acid
InChIKey: FKXDPPYCCKCVCW-LBPRGKRZSA-N
SMILES: O=C(O)C1=CC=C([C@@H](NC(C2=CC(Cl)=CN=C2OC3=CC=CC(F)=C3)=O)C)C=C1
Biological Activity: AAT-008 is a potent, selective, and orally active prostaglandin EP4 receptor antagonist with Kis of 0.97 and 6.1 nM for recombinant human EP4 and recombinant rat EP4, respectively. AAT-008 exerts tumor growth delay in mice bearing CT26WT colon tumors when combined with radiotherapy. AAT-008 can be used for the study of acute and chronic inflammatory pain and cancer [1][2].
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AAT-008 | 98.03% | AAT-008 is a potent, selective, and orally active prostaglandin EP4 receptor antagonist with Kis of 0.97 and 6.1 nM for recombinant human EP4 and recombinant rat EP4, respectively. AAT-008 exerts tumor growth delay in mice bearing CT26WT colon tumors when combined with radiotherapy. AAT-008 can be used for the study of acute and chronic inflammatory pain and cancer . | ||||||||||||||||||||
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- [1]. Okumura Y, et al. Discovery of AAT-008, a novel, potent, and selective prostaglandin EP4 receptor antagonist. Bioorg Med Chem Lett. 2017;27(5):1186-1192. [Content Brief]
- [2]. Manabe Y, et al. Biological effects of prostaglandin E2-EP4 antagonist (AAT-008) in murine colon cancer in vivo: enhancement of immune response to radiotherapy and potential as a radiosensitizer. Transl Cancer Res. 2023 Feb 28;12(2):351-358. [Content Brief]
Keywords
