847780-73-8
847780-73-8
Chemical Structure
H-Phe-Ser-Ala-OH
- CAS No.: 847780-73-8
- Formula:C15H21N3O5
- Molecular Weight:323.34
InChIKey: AFNJAQVMTIQTCB-DLOVCJGASA-N
SMILES: OC([C@H](C)NC([C@H](CO)NC([C@@H](N)CC1=CC=CC=C1)=O)=O)=O
Biological Activity: H-Phe-Ser-Ala-OH is a tripeptide and hPEPT1 ligand with a Ki value of 0.3 μM at hPEPT1 (Caco-2 cells). H-Phe-Ser-Ala-OH serves as a lead moiety for the design of hPEPT1-targeting compounds[1][2].
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H-Phe-Ser-Ala-OH | H-Phe-Ser-Ala-OH is a tripeptide and hPEPT1 ligand with a Ki value of 0.3 μM at hPEPT1 (Caco-2 cells). H-Phe-Ser-Ala-OH serves as a lead moiety for the design of hPEPT1-targeting compounds. | |||||||||||||||||||||
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References
- [1]. Thorn K, et al. Design, synthesis, and evaluation of tripeptidic promoieties targeting the intestinal peptide transporter hPEPT1. ChemMedChem. 2007 Apr;2(4):479-87.
- [2]. Omkvist DH, et al. Affinity and translocation relationships via hPEPT1 of H-X aa-Ser-OH dipeptides: evaluation of H-Phe-Ser-OH as a pro-moiety for ibuprofen and benzoic acid prodrugs. European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V. 2011 Feb;77(2):327-31. [Content Brief]
