H-Phe-Ser-Ala-OH
H-Phe-Ser-Ala-OH is a tripeptide and hPEPT1 ligand with a Ki value of 0.3 μM at hPEPT1 (Caco-2 cells). H-Phe-Ser-Ala-OH serves as a lead moiety for the design of hPEPT1-targeting compounds.
For research use only. We do not sell to patients.
- CAS No.: 847780-73-8
- Formula: C15H21N3O5
- Molecular Weight:323.34
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
In Vitro
H-Phe-Ser-Ala-OH is a high-affinity substrate of hPEPT1 in Caco-2 cell monolayers, with a Ki of 0.30 μM[1].
H-Phe-Ser-Ala-OH is efficiently transported by hPEPT1, whereas certain N-terminal modifications abolish this transport[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. .
Chemical Information
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CAS No. 847780-73-8
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Molecular Weight 323.34
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Formula C15H21N3O5
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Sequence
Phe-Ser-Ala
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Sequence Shortening
FSA
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[2]. Omkvist DH, et al. Affinity and translocation relationships via hPEPT1 of H-X aa-Ser-OH dipeptides: evaluation of H-Phe-Ser-OH as a pro-moiety for ibuprofen and benzoic acid prodrugs. European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V. 2011 Feb;77(2):327-31. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
H-Phe-Ser-Ala-OH Related Classifications
HY-P12367 Related Classifications
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