849459-88-7
849459-88-7
Chemical Structure
AC-099
- CAS No.: 849459-88-7
- Formula:C9H8ClF3N4
- Molecular Weight:264.63
IUPAC Name: (E)-2-(4-chloro-3-(trifluoromethyl)benzylidene)hydrazine-1-carboximidamide
InChIKey: SYKKEBRXRXCNEC-AYSLTRBKSA-N
SMILES: FC(C1=CC(/C=N/NC(N)=N)=CC=C1Cl)(F)F
Biological Activity: AC-099 (compound 3) is a selective NPFF2R full agonist (EC50=1189 nM) and NPFF1R partial agonist (EC50=2370 nM). AC-099 attenuates spinal nerve ligation-induced hypersensitivity in rats[1][2].
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AC-099 | AC-099 (compound 3) is a selective NPFF2R full agonist (EC50=1189 nM) and NPFF1R partial agonist (EC50=2370 nM). AC-099 attenuates spinal nerve ligation-induced hypersensitivity in rats. | |||||||||||||||||||||
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References
- [1]. Findeisen M, et al. Selective mode of action of guanidine-containing non-peptides at human NPFF receptors. J Med Chem. 2012 Jul 12;55(13):6124-36. [Content Brief]
- [2]. Gaubert G, et al. Discovery of selective nonpeptidergic neuropeptide FF2 receptor agonists. J Med Chem. 2009 Nov 12;52(21):6511-4. [Content Brief]
Keywords
