849738-78-9
Chemical Structure
AMG131 benzenesulfonate
Synonym(s): INT131 benzenesulfonate
- CAS No.: 849738-78-9
- Formula:C27H18Cl4N2O6S2
- Molecular Weight:672.38
InChIKey: ADMLKETZLUWHLX-UHFFFAOYSA-N
SMILES: O=S(O)(C1=CC=CC=C1)=O.O=S(NC2=CC(Cl)=C(C(Cl)=C2)OC3=CN=C4C=CC=CC4=C3)(C5=CC=C(C=C5Cl)Cl)=O
Biological Activity: AMG131 (INT131) (benzenesulfonate) is a potent non-thiazolidinedione (TZD) selective peroxisome proliferator-activated receptor γ modulator (SPPARM). AMG131 (benzenesulfonate) binds to PPARγ within the same binding pocket as the TZDs, but occupies a unique space in the pocket and contacts the receptor at distinct points from the TZDs. AMG131 (benzenesulfonate) is promising for research of type-2 diabetes mellitus[1][2][3].
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AMG131 benzenesulfonate | AMG131 (INT131) (benzenesulfonate) is a potent non-thiazolidinedione (TZD) selective peroxisome proliferator-activated receptor γ modulator (SPPARM). AMG131 (benzenesulfonate) binds to PPARγ within the same binding pocket as the TZDs, but occupies a unique space in the pocket and contacts the receptor at distinct points from the TZDs. AMG131 (benzenesulfonate) is promising for research of type-2 diabetes mellitus. | |||||||||||||||||||||
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- [1]. Linda S Higgins,et al. The Development of INT131 as a Selective PPARgamma Modulator: Approach to a Safer Insulin Sensitizer. PPAR Res. 2008;2008:936906. [Content Brief]
- [2]. Alykhan Motani, et al. INT131: a selective modulator of PPAR gamma. J Mol Biol. 2009 Mar 13;386(5):1301-11. [Content Brief]
- [3]. Higgins LS, et al. The Development of INT131 as a Selective PPARgamma Modulator: Approach to a Safer Insulin Sensitizer. PPAR Res. 2008;2008:936906. [Content Brief]
Keywords
