85051-41-8
85051-41-8
Chemical Structure
Norviburtinal
- CAS No.: 85051-41-8
- Formula:C9H6O2
- Molecular Weight:146.14
InChIKey: VRMFZTBAWYVGGB-UHFFFAOYSA-N
SMILES: O=CC1=CC=C2C=COC=C12
Biological Activity: Norviburtinal is a non-selective cytotoxic and pro-angiogenic agent. Norviburtinal has an IC50 of 3.25 μg/mL on G361 melanoma cells and an effective concentration of 50 μg/mL on zebrafish embryos. Norviburtinal promotes capillary sprout formation in zebrafish subintestinal vessels (SIV) and has both cytotoxic and pro-angiogenic activities. Norviburtinal can be used in research on promoting angiogenesis related to melanoma, lung cancer, and wound healing[1][2].
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Norviburtinal | Norviburtinal is a non-selective cytotoxic and pro-angiogenic agent. Norviburtinal has an IC50 of 3.25 μg/mL on G361 melanoma cells and an effective concentration of 50 μg/mL on zebrafish embryos. Norviburtinal promotes capillary sprout formation in zebrafish subintestinal vessels (SIV) and has both cytotoxic and pro-angiogenic activities. Norviburtinal can be used in research on promoting angiogenesis related to melanoma, lung cancer, and wound healing. | |||||||||||||||||||||
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References
- [1]. Liu CL, et al. Bioassay-guided isolation of norviburtinal from the root of Rehmannia glutinosa, exhibited angiogenesis effect in zebrafish embryo model. J Ethnopharmacol. 2011 Oct 11;137(3):1323-7. [Content Brief]
- [2]. Jackson SJ, et al. In vitro cytotoxicity of norviburtinal and isopinnatal from Kigelia pinnata against cancer cell lines. Planta Med. 2000 Dec;66(8):758-61. [Content Brief]
