851757-93-2
Chemical Structure
PF-376304
- CAS No.: 851757-93-2
- Formula:C17H24N8O3
- Molecular Weight:388.43
IUPAC Name: 4-(cycloheptyloxy)-2-morpholino-N-(1H-tetrazol-5-yl)pyrimidine-5-carboxamide
InChIKey: KTPKFJPJRYZTMP-UHFFFAOYSA-N
SMILES: O=C(NC1=NN=NN1)C2=CN=C(N=C2OC3CCCCCC3)N4CCOCC4
Biological Activity: PF-376304 is an orally active non-specific class I phosphoinositide 3-kinase (PI3K) inhibitor with an IC50 of 0.197 μM against PI3Kγ. PF-376304 induces dose-dependent glucose and lipid metabolic disorders in rats, causes rapid death at high doses, and leads to metabolic abnormalities that are self-reversible at low doses. PF-376304 is applicable to the research of metabolic and inflammatory diseases[1][2].
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PF-376304 | PF-376304 is an orally active non-specific class I phosphoinositide 3-kinase (PI3K) inhibitor with an IC50 of 0.197 μM against PI3Kγ. PF-376304 induces dose-dependent glucose and lipid metabolic disorders in rats, causes rapid death at high doses, and leads to metabolic abnormalities that are self-reversible at low doses. PF-376304 is applicable to the research of metabolic and inflammatory diseases. | |||||||||||||||||||||
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- [1]. Robertson DG, et al. Metabonomic evaluation of metabolic dysregulation in rats induced by PF 376304, a novel inhibitor of phosphoinositide 3-kinase. Chem Res Toxicol. 2007;20(12):1871-1877. [Content Brief]
- [2]. Ameriks MK, et al. Small molecule inhibitors of phosphoinositide 3-kinase (PI3K) delta and gamma. Curr Top Med Chem. 2009;9(8):738-53. [Content Brief]
Keywords
