856414-54-5
Chemical Structure
Sargachromanol E
- CAS No.: 856414-54-5
- Formula:C27H40O4
- Molecular Weight:428.60
IUPAC Name: (4S,5S,6E,10E)-13-((R)-6-hydroxy-2,8-dimethylchroman-2-yl)-2,6,10-trimethyltrideca-2,6,10-triene-4,5-diol
InChIKey: YIWOAJFKIIOXPS-BXYCSXDPSA-N
SMILES: C/C(C)=C\[C@@H]([C@H](/C(C)=C/CC/C(C)=C/CC[C@@]1(CCC2=CC(O)=CC(C)=C2O1)C)O)O
Biological Activity: Sargachromanol E is an apoptosis inducer, growth inhibitor, anti-inflammatory agent, and anti-aging agent. Sargachromanol E activates caspase-3, mediates PARP cleavage, downregulates Bcl-xL and upregulates Bax levels, and promotes cell cycle arrest at the sub-G1 phase. It inhibits LPS-induced transcription and expression of COX-2 and iNOS (NO: IC50 = 6.99 μg/mL), reduces the phosphorylation levels of p38 MAPK and ERK1/2, and suppresses the release of pro-inflammatory mediators including TNF‑α, IL‑1β, and prostaglandin E2. Sargachromanol E can be used in research related to leukemia, oral squamous cell carcinoma, and inflammation[1][2][3][4].
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Sargachromanol E | Sargachromanol E is an apoptosis inducer, growth inhibitor, anti-inflammatory agent, and anti-aging agent. Sargachromanol E activates caspase-3, mediates PARP cleavage, downregulates Bcl-xL and upregulates Bax levels, and promotes cell cycle arrest at the sub-G1 phase. It inhibits LPS-induced transcription and expression of COX-2 and iNOS (NO: IC50 = 6.99 μg/mL), reduces the phosphorylation levels of p38 MAPK and ERK1/2, and suppresses the release of pro-inflammatory mediators including TNF‑α, IL‑1β, and prostaglandin E2. Sargachromanol E can be used in research related to leukemia, oral squamous cell carcinoma, and inflammation. | |||||||||||||||||||||
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- [1]. Heo SJ, et al. Chromene induces apoptosis via caspase-3 activation in human leukemia HL-60 cells. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 2011 Sep;49(9):1998-2004.
- [2]. Lee JH, et al. Preparative isolation of sargachromanol E from Sargassum siliquastrum by centrifugal partition chromatography and its anti-inflammatory activity. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 2013 Dec;62:54-60.
- [3]. Natarajan PM, et al. Computational simulations of identified marine-derived natural bioactive compounds as potential inhibitors of oral cancer. Future science OA. 2022 Mar;8(3):FSO782.
- [4]. Birringer M, et al. Natural 6-hydroxy-chromanols and -chromenols: structural diversity, biosynthetic pathways and health implications. RSC advances. 2018 Jan 24;8(9):4803-4841.
Keywords
