864627-58-7
Chemical Structure
Naphthyridine carbamate dimer
Synonym(s): NCD
- CAS No.: 864627-58-7
- Formula:C26H29N7O4
- Molecular Weight:503.55
InChIKey: RLXLNYXAIXVZCE-UHFFFAOYSA-N
SMILES: O=C(NC1=NC2=C(C=C1)C=CC(C)=N2)OCCCNCCCOC(NC3=NC4=C(C=C3)C=CC(C)=N4)=O
Biological Activity: Naphthyridine carbamate dimer (NCD) is a molecular glue. Naphthyridine carbamate dimer induces designed structural changes in target functional DNA, thereby regulating its function. As a molecular glue, naphthyridine carbamate dimer stabilizes non-spontaneously formed GG homologous mismatched double-stranded DNA. Naphthyridine carbamate dimer reduces the formation of toxic RNA foci and regulates CGG repeat instability associated with fragile X syndrome and spinocerebellar ataxia type 31. Naphthyridine carbamate dimer can be used in research related to fragile X syndrome and spinocerebellar ataxia type 31[1][2][3].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
|
Naphthyridine carbamate dimer | 98.22% | Naphthyridine carbamate dimer (NCD) is a molecular glue. Naphthyridine carbamate dimer induces designed structural changes in target functional DNA, thereby regulating its function. As a molecular glue, naphthyridine carbamate dimer stabilizes non-spontaneously formed GG homologous mismatched double-stranded DNA. Naphthyridine carbamate dimer reduces the formation of toxic RNA foci and regulates CGG repeat instability associated with fragile X syndrome and spinocerebellar ataxia type 31. Naphthyridine carbamate dimer can be used in research related to fragile X syndrome and spinocerebellar ataxia type 31. | ||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
References
- [1]. Yamada T, et al. NMR determination of the 2:1 binding complex of naphthyridine carbamate dimer (NCD) and CGG/CGG triad in double-stranded DNA. Nucleic acids research. 2022 Sep 23;50(17):9621-9631. [Content Brief]
- [2]. Simeth NA, et al. Rational design of a photoswitchable DNA glue enabling high regulatory function and supramolecular chirality transfer. Chemical science. 2021 Jul 07;12(26):9207-9220. [Content Brief]
- [3]. Mateja-Pluta M, et al. Naphthyridine carbamate dimer ligand induces formation of Z-RNA-like fold of disease-related RNA and exhibits a molecular glue characteristics in crystal lattice formation. Nucleic acids research. 2025 Sep 05;53(17):gkaf924.
