864972-30-5
Chemical Structure
C108297
- CAS No.: 864972-30-5
- Formula:C30H36FN3O4S
- Molecular Weight:553.69
IUPAC Name: (R)-6-((4-(tert-butyl)phenyl)sulfonyl)-1-(4-fluorophenyl)-4a-((2-methoxyethoxy)methyl)-4,4a,5,6,7,8-hexahydro-1H-pyrazolo[3,4-g]isoquinoline
InChIKey: OMKDFVUMRKROMY-SSEXGKCCSA-N
SMILES: COCCOC[C@]12CC3=C(C=C1CCN(C2)S(=O)(C4=CC=C(C=C4)C(C)(C)C)=O)N(N=C3)C5=CC=C(C=C5)F
Biological Activity: C108297 is a selective glucocorticoid receptor (GR) modulator (GR binding Ki 0.7 nM; GR reporter gene functional Ki 0.6 nM). C108297 attenuates obesity by reducing caloric intake and increasing lipolysis and fat oxidation, and in addition attenuates inflammation[1][2].
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C108297 | 99.97% | C108297 is a selective glucocorticoid receptor (GR) modulator (GR binding Ki 0.7 nM; GR reporter gene functional Ki 0.6 nM). C108297 attenuates obesity by reducing caloric intake and increasing lipolysis and fat oxidation, and in addition attenuates inflammation. | ||||||||||||||||||||
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- [1]. Clark RD, et al. 1H-Pyrazolo[3,4-g]hexahydro-isoquinolines as selective glucocorticoid receptor antagonists with high functional activity. Bioorg Med Chem Lett. 2008;18(4):1312-1317. [Content Brief]
- [2]. van den Heuvel JK, et al. Identification of a selective glucocorticoid receptor modulator that prevents both diet-induced obesity and inflammation. Br J Pharmacol. 2016;173(11):1793-1804. [Content Brief]
Keywords
