869974-19-6
Chemical Structure
INCB13739
- CAS No.: 869974-19-6
- Formula:C28H25N3O4
- Molecular Weight:467.52
IUPAC Name: (R)-N-methyl-5-(4-(1-(3-oxo-3H-spiro[isobenzofuran-1,3'-pyrrolidine]-1'-carbonyl)cyclopropyl)phenyl)picolinamide
InChIKey: BDQCDIWFPIDPQU-NDEPHWFRSA-N
SMILES: O=C(C1=NC=C(C2=CC=C(C3(C(N4C[C@]5(CC4)OC(C6=C5C=CC=C6)=O)=O)CC3)C=C2)C=C1)NC
Biological Activity: INCB13739 is an orally active, potent, selective and tissue-specific11β-HSD1 (11β-hydroxysteroid dehydrogenase 1) inhibitor, with IC50 values of 3.2 nM (11β-HSD1 enzymatic) and 1.1 nM (11β-HSD1 PBMC), respectively. INCB13739 can be used for type 2 diabetes mellitus (T2DM) and obesity research[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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INCB13739 | 99.79% | INCB13739 is an orally active, potent, selective and tissue-specific11β-HSD1 (11β-hydroxysteroid dehydrogenase 1) inhibitor, with IC50 values of 3.2 nM (11β-HSD1 enzymatic) and 1.1 nM (11β-HSD1 PBMC), respectively. INCB13739 can be used for type 2 diabetes mellitus (T2DM) and obesity research. | ||||||||||||||||||||
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- [1]. Marando C, et al. Discovery of 1'-(1-phenylcyclopropane-carbonyl)-3H-spiro[isobenzofuran-1,3'-pyrrolidin]-3-one as a novel steroid mimetic scaffold for the potent and tissue-specific inhibition of 11β-HSD1 using a scaffold-hopping approach. Bioorg Med Chem Lett. 2022 Aug 1;69:128782. [Content Brief]
Keywords
