87-41-2
Chemical Structure
Phthalide
- CAS No.: 87-41-2
- Formula:C8H6O2
- Molecular Weight:134.13
IUPAC Name: isobenzofuran-1(3H)-one
InChIKey: WNZQDUSMALZDQF-UHFFFAOYSA-N
SMILES: O=C1OCC2=C1C=CC=C2
Biological Activity: Phthalide is a chemical scaffold. Phthalide derivatives act as potent blood-brain barrier modulators. Phthalide exhibits significant anti-inflammatory activity. Some phthalide derivatives possess anti-inflammatory activity. The phthalide derivative Senkyunolide I shows analgesic effects and ameliorates cerebral edema and cerebral infarction volume in rats with focal cerebral ischemia-reperfusion injury. Phthalide can be used in research related to glioma, rheumatoid arthritis, malaria, bacterial infection, fungal infection and ischemic stroke[1][2][3][4].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Phthalide | 99.94% | Phthalide is a chemical scaffold. Phthalide derivatives act as potent blood-brain barrier modulators. Phthalide exhibits significant anti-inflammatory activity. Some phthalide derivatives possess anti-inflammatory activity. The phthalide derivative Senkyunolide I shows analgesic effects and ameliorates cerebral edema and cerebral infarction volume in rats with focal cerebral ischemia-reperfusion injury. Phthalide can be used in research related to glioma, rheumatoid arthritis, malaria, bacterial infection, fungal infection and ischemic stroke. | ||||||||||||||||||||
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Phthalide (Standard) | ≥98% | Phthalide (Standard) is an analytical standard of Phthalide. This product is intended for research and analytical applications. Phthalide is a chemical scaffold. Phthalide can be used to synthesize a variety of phthalate derivatives, including anti-inflammatory agents, antimicrobial agents, antioxidants and blood-tumor barrier regulators. | ||||||||||||||||||||
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References
- [1]. Liu X, et al. Six Phthalides as Potent Modulators of the Blood Tumor Barrier Increase the Transmembrane Transport of Compatible Compounds Via Transcellular and Paracellular Pathways[J]. Pharmaceutical Chemistry Journal, 2024, 57(12): 1967-1976.
- [2]. Chen LZ, et al. Novel phthalide derivatives: Synthesis and anti-inflammatory activity in vitro and in vivo. European journal of medicinal chemistry. 2020 Nov 15;206:112722. [Content Brief]
- [3]. Intaraudom C, et al. Antimicrobial drimane - phthalide derivatives from Hypoxylon fendleri BCC32408. Fitoterapia. 2019 Oct;138:104353. [Content Brief]
- [4]. Fang X, et al. Synthesis of phthalide derivatives and evaluation on their antiplatelet aggregation and antioxidant activities. Journal of Asian natural products research. 2020 Dec;22(12):1176-1187. [Content Brief]
