87-41-2
87-41-2
Chemical Structure
Phthalide
- CAS No.: 87-41-2
- Formula:C8H6O2
- Molecular Weight:134.13
IUPAC Name: isobenzofuran-1(3H)-one
InChIKey: WNZQDUSMALZDQF-UHFFFAOYSA-N
SMILES: O=C1OCC2=C1C=CC=C2
Biological Activity: Phthalide is a chemical scaffold. Phthalide derivatives act as potent blood-brain barrier modulators. Phthalide exhibits significant anti-inflammatory activity. Some phthalide derivatives possess anti-inflammatory activity. The phthalide derivative Senkyunolide I shows analgesic effects and ameliorates cerebral edema and cerebral infarction volume in rats with focal cerebral ischemia-reperfusion injury. Phthalide can be used in research related to glioma, rheumatoid arthritis, malaria, bacterial infection, fungal infection and ischemic stroke[1][2][3][4].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Phthalide | 99.95% | Phthalide is a chemical scaffold. Phthalide derivatives act as potent blood-brain barrier modulators. Phthalide exhibits significant anti-inflammatory activity. Some phthalide derivatives possess anti-inflammatory activity. The phthalide derivative Senkyunolide I shows analgesic effects and ameliorates cerebral edema and cerebral infarction volume in rats with focal cerebral ischemia-reperfusion injury. Phthalide can be used in research related to glioma, rheumatoid arthritis, malaria, bacterial infection, fungal infection and ischemic stroke. | ||||||||||||||||||||
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Phthalide (Standard) | ≥98% | Phthalide (Standard) is an analytical standard of Phthalide. This product is intended for research and analytical applications. Phthalide is a chemical scaffold. Phthalide can be used to synthesize a variety of phthalate derivatives, including anti-inflammatory agents, antimicrobial agents, antioxidants and blood-tumor barrier regulators. | ||||||||||||||||||||
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(3S)-Butylphthalide | (3S)-Butylphthalide is a phthalide and can be isolated from A. graveolens. (3S)-Butylphthalide has antiplatelet and neuroprotective activities. | |||||||||||||||||||||
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Butylphthalide (Standard) | ≥98% | Butylphthalide (Standard) is the analytical standard of Butylphthalide. This product is intended for research and analytical applications. Butylphthalide (3-n-Butylphthalide) is an active molecule against cerebral ischemia. It was originally isolated from celery species and has been shown to be effective in stroke animal models. | ||||||||||||||||||||
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Erythrocentaurin | Erythrocentaurin, a natural compound, is a new class of hepatitis B virus inhibitor. | |||||||||||||||||||||
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5,7-Dihydroxyphthalide | 5,7-Dihydroxyphthalide is a natural phenolic compound. | |||||||||||||||||||||
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3-Hydroxyphthalic anhydride | 99.43% | 4-Hydroxyisobenzofuran-1,3-dione is a biochemical reagent that can be used as a biological material or organic compound for life science related research. | ||||||||||||||||||||
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5-Bromophthalide | 99.60% | 5-Bromophthalide is an intermediate. 5-Bromophthalide is used in the synthesis of the antidepressant Escitalopram (HY-14258) and antibacterial agents. | ||||||||||||||||||||
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4-Fluorophthalic anhydride | 97.0% | 4-Fluorophthalic anhydride is a highly efficient defect passivation additive for perovskite solar cells, which can improve the efficiency and stability of the cells. | ||||||||||||||||||||
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4-Methylphthalic anhydride | 4-Methylphthalic anhydride is an organic acid anhydride and an immunogen/sensitizer. 4-Methylphthalic anhydride induces the production of specific immunoglobulin E and immunoglobulin G antibodies. 4-Methylphthalic anhydride is used in studies of occupational allergy. | |||||||||||||||||||||
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Meconine (Standard) | 98.60% | Meconine (Standard) is the analytical standard of Meconine (HY-W019151). This product is intended for research and analytical applications. Meconine is the urinary metabolite of Noscapine (HY-13716) and also a phase I metabolite of Bromonoscapine. Meconine can serve as a complementary biomarker in addition to opioid metabolites. | ||||||||||||||||||||
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References
- [1]. Liu X, et al. Six Phthalides as Potent Modulators of the Blood Tumor Barrier Increase the Transmembrane Transport of Compatible Compounds Via Transcellular and Paracellular Pathways[J]. Pharmaceutical Chemistry Journal, 2024, 57(12): 1967-1976.
- [2]. Chen LZ, et al. Novel phthalide derivatives: Synthesis and anti-inflammatory activity in vitro and in vivo. European journal of medicinal chemistry. 2020 Nov 15;206:112722. [Content Brief]
- [3]. Intaraudom C, et al. Antimicrobial drimane - phthalide derivatives from Hypoxylon fendleri BCC32408. Fitoterapia. 2019 Oct;138:104353. [Content Brief]
- [4]. Fang X, et al. Synthesis of phthalide derivatives and evaluation on their antiplatelet aggregation and antioxidant activities. Journal of Asian natural products research. 2020 Dec;22(12):1176-1187. [Content Brief]
