871978-21-1
Chemical Structure
AM841
- CAS No.: 871978-21-1
- Formula:C26H39NO3S
- Molecular Weight:445.66
IUPAC Name: (6aR,9R,10aR)-9-(hydroxymethyl)-3-(8-isothiocyanato-2-methyloctan-2-yl)-6,6-dimethyl-6a,7,8,9,10,10a-hexahydro-6H-benzo[c]chromen-1-ol
InChIKey: JCIYJYHFBBXSBF-HMXCVIKNSA-N
SMILES: OC1=C2[C@@]3([H])[C@](CC[C@H](C3)CO)([H])C(C)(OC2=CC(C(C)(C)CCCCCCN=C=S)=C1)C
Biological Activity: AM841 is a high-affinity electrophilic ligand. AM841 interacts covalently with a cysteine in helix six and activates the CB1 cannabinoid receptor. AM841 reduces Forskolin (HY-15371)-stimulated cAMP accumulation. AM841 also slows gastrointestinal motility[1][2].
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AM841 | AM841 is a high-affinity electrophilic ligand. AM841 interacts covalently with a cysteine in helix six and activates the CB1 cannabinoid receptor. AM841 reduces Forskolin (HY-15371)-stimulated cAMP accumulation. AM841 also slows gastrointestinal motility. | |||||||||||||||||||||
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- [1]. Picone RP, et al. (-)-7'-Isothiocyanato-11-hydroxy-1',1'-dimethylheptylhexahydrocannabinol (AM841), a high-affinity electrophilic ligand, interacts covalently with a cysteine in helix six and activates the CB1 cannabinoid receptor. Mol Pharmacol. 2005 Dec;68(6):1623-35. [Content Brief]
- [2]. Keenan CM, et al. AM841, a covalent cannabinoid ligand, powerfully slows gastrointestinal motility in normal and stressed mice in a peripherally restricted manner. Br J Pharmacol. 2015 May;172(9):2406-18. [Content Brief]
Keywords
