874351-38-9
874351-38-9
Chemical Structure
JUN-1111
- CAS. Nr.: 874351-38-9
- Formula:C15H17N3O3
- Molecular Weight:287.31
IUPAC Name: 7-((2-morpholinoethyl)amino)quinoline-5,8-dione
InChIKey: QWIRJCMQNFHGJV-UHFFFAOYSA-N
SMILES: O=C(C=C1NCCN2CCOCC2)C3=C(N=CC=C3)C1=O
Biological Activity: JUN-1111 is an irreversible and selective Cdc25 phosphatase inhibitor with IC50 values of 0.38, 1.8, 0.66, 28, 37 µM for Cdc25A, Cdc25B, Cdc25C, VHR, PTP1B, respectively. JUN-1111 induces cell cycle arrest at G1 and G2/M phases. JUN-1111 decreases the expression of phosphoCdk1[1][2].
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JUN-1111 | 98.57% | JUN-1111 is an irreversible and selective Cdc25 phosphatase inhibitor with IC50 values of 0.38, 1.8, 0.66, 28, 37 µM for Cdc25A, Cdc25B, Cdc25C, VHR, PTP1B, respectively. JUN-1111 induces cell cycle arrest at G1 and G2/M phases. JUN-1111 decreases the expression of phosphoCdk1. | ||||||||||||||||||||
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References
- [1]. Brisson M, et al. Redox regulation of Cdc25B by cell-active quinolinediones. Mol Pharmacol. 2005 Dec;68(6):1810-20. [Content Brief]
- [2]. Vogt A, et al. A cell-active inhibitor of mitogen-activated protein kinase phosphatases restores paclitaxel-induced apoptosis in dexamethasone-protected cancer cells. Mol Cancer Ther. 2008 Feb;7(2):330-40. [Content Brief]
