87858-57-9
87858-57-9
Chemical Structure
AD 4743
Synonym(s): ADD 4743
- CAS No.: 87858-57-9
- Formula:C18H23NO4S
- Molecular Weight:349.44
IUPAC Name: 5-(4-((3-hydroxy-1-methylcyclohexyl)methoxy)benzyl)thiazolidine-2,4-dione
InChIKey: AVOKTXBQCWLDRM-UHFFFAOYSA-N
SMILES: O=C(N1)SC(CC2=CC=C(OCC3(C)CC(O)CCC3)C=C2)C1=O
Biological Activity: AD 4743 (ADD 4743) is a metabolite of Ciglitazone (HY-W011220). AD 4743 is an adipogenic agent. AD 4743 induces FPRP accumulation and accumulation of lipid droplets. AD 4743 inhibits cell proliferation of preadipose cells[1][2].
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AD 4743 | AD 4743 (ADD 4743) is a metabolite of Ciglitazone (HY-W011220). AD 4743 is an adipogenic agent. AD 4743 induces FPRP accumulation and accumulation of lipid droplets. AD 4743 inhibits cell proliferation of preadipose cells. | |||||||||||||||||||||
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References
- [1]. Orlicky DJ, et al. Synthesis and accumulation of a receptor regulatory protein associated with lipid droplet accumulation in 3T3-L1 cells. J Lipid Res. 1998 Jun;39(6):1152-61. [Content Brief]
- [2]. Hiragun A, et al. Preadipocyte differentiation in vitro: identification of a highly active adipogenic agent. J Cell Physiol. 1988 Jan;134(1):124-30. [Content Brief]
