889115-58-6
Chemical Structure
(Rac)-LY-2300559
- CAS No.: 889115-58-6
- Formula:C26H26O6
- Molecular Weight:434.49
IUPAC Name: 3-((4-((4-acetyl-3-hydroxy-2-propylphenoxy)methyl)phenyl)(hydroxy)methyl)benzoic acid
InChIKey: DWQVYDLTPMGYNE-UHFFFAOYSA-N
SMILES: O=C(O)C1=CC=CC(=C1)C(O)C2=CC=C(C=C2)COC3=CC=C(C(=O)C)C(O)=C3CCC
Biological Activity: (Rac)-LY-2300559 is a positive allosteric modulator of metabotropic glutamate receptor 2 (mGlu2) and an antagonist of cysteinyl leukotriene 1 (CysLT1) receptor, with both EC50 and IC50 values less than 12.5 μM. (Rac)-LY-2300559 enhances glutamate-induced mGlu2 receptor signaling while exerting antagonistic activity against the CysLT1 receptor. (Rac)-LY-2300559 can be used in migraine-related research[1].
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(Rac)-LY-2300559 | (Rac)-LY-2300559 is a positive allosteric modulator of metabotropic glutamate receptor 2 (mGlu2) and an antagonist of cysteinyl leukotriene 1 (CysLT1) receptor, with both EC50 and IC50 values less than 12.5 μM. (Rac)-LY-2300559 enhances glutamate-induced mGlu2 receptor signaling while exerting antagonistic activity against the CysLT1 receptor. (Rac)-LY-2300559 can be used in migraine-related research. | |||||||||||||||||||||
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