88949-01-3
Chemical Structure
BMY 25282
Synonym(s): BL 6782
- CAS No.: 88949-01-3
- Formula:C18H23N5O5
- Molecular Weight:389.41
IUPAC Name: ((1aS,8S,8aR,8bS)-6-(((E)-(dimethylamino)methylene)amino)-8a-methoxy-5-methyl-4,7-dioxo-1,1a,2,4,7,8,8a,8b-octahydroazirino[2',3':3,4]pyrrolo[1,2-a]indol-8-yl)methyl carbamate
InChIKey: WZMFNIVNLYRDDE-ZCMHTCKSSA-N
SMILES: CO[C@]12N(C[C@H]3[C@@H]2N3)C4=C(C(C(/N=C/N(C)C)=C(C)C4=O)=O)[C@H]1COC(N)=O
Biological Activity: BMY 25282 (BL 6782) is a mitomycin C (MMC) analog. BMY 25282 catalyzes oxygen activation in hepatocytes. BMY 25282 overcomes MMC tolerance in colon cancer cells and mouse models of colon cancer. BMY 25282 inhibits tumor growth in mouse models of leukemia and melanoma. BMY 25282 can be used in research on cancers such as leukemia, melanoma, and colon cancer[1][2][3].
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BMY 25282 | BMY 25282 (BL 6782) is a mitomycin C (MMC) analog. BMY 25282 catalyzes oxygen activation in hepatocytes. BMY 25282 overcomes MMC tolerance in colon cancer cells and mouse models of colon cancer. BMY 25282 inhibits tumor growth in mouse models of leukemia and melanoma. BMY 25282 can be used in research on cancers such as leukemia, melanoma, and colon cancer. | |||||||||||||||||||||
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- [1]. Silva JM, et al. Contrasting molecular cytotoxic mechanisms of mitomycin C and its two analogs, BMY 25282 and BMY 25067, in isolated rat hepatocytes. Biochem Pharmacol. 1993 Jun 9;45(11):2303-9. [Content Brief]
- [2]. Willson JK, et al. Effects of BMY 25282, a mitomycin C analogue, in mitomycin C-resistant human colon cancer cells. Cancer Res. 1985 Nov;45(11 Pt 1):5281-6. [Content Brief]
- [3]. Bradner WT, et al. Antitumor activity and toxicity in animals of BMY-25282, a new mitomycin derivative. Cancer Res. 1985 Dec;45(12 Pt 1):6475-81. [Content Brief]
Keywords
