889860-85-9
Chemical Structure
GAT229
- CAS No.: 889860-85-9
- Formula:C22H18N2O2
- Molecular Weight:342.39
IUPAC Name: (S)-3-(2-nitro-1-phenylethyl)-2-phenyl-1H-indole
InChIKey: OHZDCJJHWPHZJD-IBGZPJMESA-N
SMILES: O=[N+](C[C@H](C1=C(C2=CC=CC=C2)NC3=C1C=CC=C3)C4=CC=CC=C4)[O-]
Biological Activity: GAT229 is a CB1 positive allosteric modulator (PAM) that effectively reduces intraocular pressure (IOP) in high IOP mouse models and enhances CB1 receptor-mediated IOP-lowering effects. A 0.2% GAT229 solution or 10 mg/kg of GAT229 alone significantly reduces IOP. GAT229 is promising for research related to glaucoma and elevated intraocular pressure[1].
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GAT229 | GAT229 is a CB1 positive allosteric modulator (PAM) that effectively reduces intraocular pressure (IOP) in high IOP mouse models and enhances CB1 receptor-mediated IOP-lowering effects. A 0.2% GAT229 solution or 10 mg/kg of GAT229 alone significantly reduces IOP. GAT229 is promising for research related to glaucoma and elevated intraocular pressure. | |||||||||||||||||||||
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Keywords
