89112-85-6
89112-85-6
Chemical Structure
2'MeO6MF
- CAS No.: 89112-85-6
- Formula:C17H14O3
- Molecular Weight:266.29
IUPAC Name: 2-(2-methoxyphenyl)-6-methyl-4H-chromen-4-one
InChIKey: QEIHFNZSIRWEBX-UHFFFAOYSA-N
SMILES: O=C1C=C(C2=CC=CC=C2OC)OC3=CC=C(C)C=C13
Biological Activity: 2'MeO6MF is a brain-penetrant positive allosteric modulator at α2β1γ2L and all α1-containing GABAA receptors. 2'MeO6MF also can directly activate α2β2/3 and α2β2/3γ2L GABAA receptors. 2'MeO6MF has anxiolytic and psychomotor stabilizing properties. 2'MeO6MF offers neuroprotection and improved functional recovery and dampens the stroke-induced inflammatory response[1][2].
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2'MeO6MF | 2'MeO6MF is a brain-penetrant positive allosteric modulator at α2β1γ2L and all α1-containing GABAA receptors. 2'MeO6MF also can directly activate α2β2/3 and α2β2/3γ2L GABAA receptors. 2'MeO6MF has anxiolytic and psychomotor stabilizing properties. 2'MeO6MF offers neuroprotection and improved functional recovery and dampens the stroke-induced inflammatory response. | |||||||||||||||||||||
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References
- [1]. Karim N, et, al. 2'-Methoxy-6-methylflavone: a novel anxiolytic and sedative with subtype selective activating and modulating actions at GABA(A) receptors. Br J Pharmacol. 2012 Feb;165(4):880-96. [Content Brief]
- [2]. Clarkson AN, et, al. The flavonoid, 2'-methoxy-6-methylflavone, affords neuroprotection following focal cerebral ischaemia. J Cereb Blood Flow Metab. 2019 Jul;39(7):1266-1282. [Content Brief]
