893556-85-9
Chemical Structure
PF-945863
- CAS No.: 893556-85-9
- Formula:C44H65N5O10
- Molecular Weight:824.01
IUPAC Name: (3aS,4R,7R,9R,10R,11R,13R,15R,15aR)-1-(1-((R)-1-(1,8-naphthyridin-4-yl)ethyl)azetidin-3-yl)-10-(((2S,3R,4S,6R)-4-(dimethylamino)-3-hydroxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)-4-ethyl-11-methoxy-3a,7,9,11,13,15-hexamethyloctahydro-2H-[1]oxacyclotetradeci
InChIKey: FATPJRUUPNLGGR-IPOVFCFTSA-N
SMILES: O=C1N(C2CN([C@@H](C3=CC=NC4=C3C=CC=N4)C)C2)[C@@]([C@H]5C)([H])[C@@](C)([C@H](OC([C@@H](C([C@H](C)[C@@H](O[C@@]6([H])[C@@H]([C@H](C[C@@H](C)O6)N(C)C)O)[C@@](OC)(C)C[C@@H](C)C5=O)=O)C)=O)CC)O1
Biological Activity: PF-945863 is an orally active macrolide antibiotic that can be used for the research of multidrug resistant respiratory tract bacterial strains[1][2].
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PF-945863 | PF-945863 is an orally active macrolide antibiotic that can be used for the research of multidrug resistant respiratory tract bacterial strains. | |||||||||||||||||||||
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- [1]. Zientek M, et al. In vitro-in vivo correlation for intrinsic clearance for drugs metabolized by human aldehyde oxidase. Drug Metab Dispos. 2010;38(8):1322-1327. [Content Brief]
- [2]. Magee TV, et al. Discovery of azetidinyl ketolides for the treatment of susceptible and multidrug resistant community-acquired respiratory tract infections. J Med Chem. 2009;52(23):7446-7457. [Content Brief]
Keywords
