89366-02-9
Chemical Structure
Nimolicinol
- CAS No.: 89366-02-9
- Formula:C28H34O7
- Molecular Weight:482.57
IUPAC Name: (1S,4bR,5R,6aR,10aR,10bR,12aR)-1-(furan-3-yl)-1-hydroxy-4b,7,7,10a,12a-pentamethyl-3,8-dioxo-3,4b,5,6,6a,7,8,10a,10b,11,12,12a-dodecahydro-1H-naphtho[2,1-f]isochromen-5-yl acetate
InChIKey: VXKRRVRNHBWLTO-VBPYNQNZSA-N
SMILES: C[C@]12C([C@]([C@](O3)(C4=COC=C4)O)(CC[C@]1([H])[C@@]5([C@@](C(C)(C(C=C5)=O)C)([H])C[C@H]2OC(C)=O)C)C)=CC3=O
Biological Activity: Nimolicinol is a tetranortriterpenoid compound. Nimolicinol binds to the ephrinB2 interaction interface of the Nipah virus attachment glycoprotein, interfering with virus-host cell adhesion, and exhibits anti-Plasmodium, anti-SARS-CoV-2, and larvicidal activities. Nimolicinol can be used in research on Nipah virus infection, malaria, COVID-19, and filariasis[1][2][3][4][5].
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Nimolicinol | Nimolicinol is a tetranortriterpenoid compound. Nimolicinol binds to the ephrinB2 interaction interface of the Nipah virus attachment glycoprotein, interfering with virus-host cell adhesion, and exhibits anti-Plasmodium, anti-SARS-CoV-2, and larvicidal activities. Nimolicinol can be used in research on Nipah virus infection, malaria, COVID-19, and filariasis. | |||||||||||||||||||||
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References
- [1]. de Oliveira VM, et al. Molecular Docking and Dynamics Simulations of Natural Limonoids Interacting with the Nipah Virus Attachment Glycoprotein. Current drug targets. 2026 Jun 08.
- [2]. Hallur G, et al. Three new tetranortriterpenoids from neem seed oil. Journal of natural products. 2002 Aug;65(8):1177-9.
- [3]. Khanal, et al. In silico docking study of limonoids from Azadirachta indica with pfpk5 a novel target for Plasmodium falciparum. Indian Journal of Pharmaceutical Sciences (2019).
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[4]. Victor Moreira de Oliveira, et al. Molecular docking identification for the efficacy of natural limonoids against COVID-19 virus main protease, Journal of the Indian Chemical Society, Volume 98, Issue 10, 2021, 100157, ISSN 0019-4522.
- [5]. Gurulingappa H, et al. Susceptibility of Aedes aegypti and Culex quinquefasciatus Larvae to gedunin-related limonoids. Chemistry & biodiversity. 2009 Jun;6(6):897-902.
