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Cat. No.: HY-W663542

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Nimolicinol

Nimolicinol is a tetranortriterpenoid compound. Nimolicinol binds to the ephrinB2 interaction interface of the Nipah virus attachment glycoprotein, interfering with virus-host cell adhesion, and exhibits anti-Plasmodium, anti-SARS-CoV-2, and larvicidal activities. Nimolicinol can be used in research on Nipah virus infection, malaria, COVID-19, and filariasis.

For research use only. We do not sell to patients.

CAS No.: 89366-02-9
Formula: C₂₈H₃₄O₇
Molecular Weight:482.57

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Nimolicinol Chemical Structure

CAS No.: 89366-02-9

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
- In Vitro
- In Vivo
Chemical Information
Protocols (1)
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

All Parasite Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
HL-60	IC₅₀	> 20 μM Compound: 19	Cytotoxicity against human HL60 cells assessed as cell viability after 48 hrs by MTT assay Cytotoxicity against human HL60 cells assessed as cell viability after 48 hrs by MTT assay	[PMID: 21381696]
SK-BR-3	IC₅₀	> 20 μM Compound: 19	Cytotoxicity against human SK-BR-3 cells assessed as cell viability after 48 hrs by MTT assay Cytotoxicity against human SK-BR-3 cells assessed as cell viability after 48 hrs by MTT assay	[PMID: 21381696]
A549	IC₅₀	> 20 μM Compound: 19	Cytotoxicity against human A549 cells assessed as cell viability after 48 hrs by MTT assay Cytotoxicity against human A549 cells assessed as cell viability after 48 hrs by MTT assay	[PMID: 21381696]
AZ-521 cell line	IC₅₀	> 20 μM Compound: 19	Cytotoxicity against human AZ-521 cells assessed as cell viability after 48 hrs by MTT assay Cytotoxicity against human AZ-521 cells assessed as cell viability after 48 hrs by MTT assay	[PMID: 21381696]

In Vitro

Nimolicinol (NCL) binds the Nipah virus attachment glycoprotein with a docking ΔG of -9.265 kcal/mol (RMSD 1.957 Å), interacting with Leu124, Asp219, Phe458, Val507, and Lys560 through hydrophobic contacts, with Tyr508 and Gln559 through hydrogen bonds, and with Arg236 through a salt bridge, all within Cavity I^[1].
Nimolicinol (compound 4) is a known tetranortriterpenoid isolated from Azadirachta indica neem seed oil^[2].
Nimolicinol binds to pfpk5 through hydrogen bonding and pi interactions, with a binding energy of -5.5 kcal/mol, exhibiting the highest binding affinity among the tested limonoids and supporting its potential as a pfpk5 inhibitor^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.

In Vivo

Nimolicinol (10-50 ppm; aqueous larval medium) exhibited weak larvicidal activity against Aedes aegypti, causing only 20% mortality after 48 h at 50 ppm and 10 ppm^[5].
Nimolicinol (10-50 ppm; aqueous larval medium) exhibited weak larvicidal activity against Culex quinquefasciatus, causing 30% mortality at 50 ppm and 15% mortality at 10 ppm after 48 h^[5].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Aedes aegypti (fourth instar larvae)^[5]
Dosage:

50 ppm; 10 ppm
Administration:

aqueous larval medium
Result:

Produced 20% mortality at 48 h at 10 and 50 ppm.

Animal Model:

Culex quinquefasciatus (fourth instar larvae)^[5]
Dosage:

50 ppm; 10 ppm
Administration:

aqueous larval medium
Result:

Produced 30% mortality at 48 h at 10 and 50 ppm.

Chemical Information

CAS No. 89366-02-9
Molecular Weight 482.57
Formula C₂₈H₃₄O₇
SMILES

C[C@]12C([C@]([C@](O3)(C4=COC=C4)O)(CC[C@]1([H])[C@@]5([C@@](C(C)(C(C=C5)=O)C)([H])C[C@H]2OC(C)=O)C)C)=CC3=O
Structure Classification
- Terpenoids
- Triterpenes
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Protocols

All Signal Pathway Related

Research Protocol for Infectious Diseases
Infectious-disease experiments test how pathogens interact with host barriers, innate immune receptors, inflammatory signaling, pathogen replication, and tissue injury; pattern-recognition receptors such as TLRs, RIG-I-like receptors, NOD-like receptors, and inflammasomes detect microbial molecules and activate NF-κB, interferon, and cytokine responses. The central hypothesis is that infection severity reflects the balance between pathogen burden and host response: protective inflammation restricts pathogen growth, whereas excessive or mislocalized inflammation contributes to tissue damage and disease phenotype. Unresolved questions include which host pathways are protective versus pathogenic, why some infection models fail to translate to human disease, and which combined readouts best predict clinically relevant infection outcomes.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. de Oliveira VM, et al. Molecular Docking and Dynamics Simulations of Natural Limonoids Interacting with the Nipah Virus Attachment Glycoprotein. Current drug targets. 2026 Jun 08.

[2]. Hallur G, et al. Three new tetranortriterpenoids from neem seed oil. Journal of natural products. 2002 Aug;65(8):1177-9.

[3]. Khanal, et al. In silico docking study of limonoids from Azadirachta indica with pfpk5 a novel target for Plasmodium falciparum. Indian Journal of Pharmaceutical Sciences (2019).

[4]. Victor Moreira de Oliveira, et al. Molecular docking identification for the efficacy of natural limonoids against COVID-19 virus main protease, Journal of the Indian Chemical Society, Volume 98, Issue 10, 2021, 100157, ISSN 0019-4522.

[5]. Gurulingappa H, et al. Susceptibility of Aedes aegypti and Culex quinquefasciatus Larvae to gedunin-related limonoids. Chemistry & biodiversity. 2009 Jun;6(6):897-902.

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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