899433-49-9
Chemical Structure
ISO-92
- CAS No.: 899433-49-9
- Formula:C16H20FNO4
- Molecular Weight:309.33
IUPAC Name: neopentyl (R)-2-(3-(3-fluoro-4-hydroxyphenyl)-4,5-dihydroisoxazol-5-yl)acetate
InChIKey: DATAZFQRJUJYCR-LLVKDONJSA-N
SMILES: O=C(OCC(C)(C)C)C[C@H]1CC(C2=CC=C(O)C(F)=C2)=NO1
Biological Activity: ISO-92 in an inhibitor of MIF. ISO-92 selectively inhibits MIF inflammatory activity with an IC50 of 550 nM. ISO-92 inhibits hypoxia-induced proliferation of CCL-210 cell line dose-dependently. ISO-92 significantly reduces the thickness of pulmonary vascular wall in mouse hypoxia models. ISO-92 can be studied in inflammatory and neurological research[1][2].
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ISO-92 | ISO-92 in an inhibitor of MIF. ISO-92 selectively inhibits MIF inflammatory activity with an IC50 of 550 nM. ISO-92 inhibits hypoxia-induced proliferation of CCL-210 cell line dose-dependently. ISO-92 significantly reduces the thickness of pulmonary vascular wall in mouse hypoxia models. ISO-92 can be studied in inflammatory and neurological research. | |||||||||||||||||||||
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- [1]. Perveen, S., et al., (2019). MIF inhibition enhances pulmonary angiogenesis and lung development in congenital diaphragmatic hernia. Pediatric research, 85(5), 711-718. [Content Brief]
- [2]. Zhang, Y., et al., (2012). Macrophage migration inhibitory factor mediates hypoxia-induced pulmonary hypertension. Molecular medicine (Cambridge, Mass.), 18(1), 215-223. [Content Brief]
Keywords
